Difficulty urinating is a symptom of difficult urination, which is caused by more reasons, generally seen in prostatic hyperplasia, urethral stricture, bladder disease, etc. It may also be affected by psychological factors or drugs. 1, prostatic hyperplasia: Difficulty urinating is a common symptom of patients with prostatic hyperplasia, which can be treated with drugs such as 5 alpha-reductase inhibitors, alpha-blockers, etc. In severe cases, surgery can be used; 2. Urethral stricture: mainly seen as a result of urethral inflammation, because inflammation can stimulate the urethra, appearing congestion, edema and other reactions, thus leading to urethral stricture and difficulty in urination, which can be treated with medication. If bacterial infection can choose cephalosporins, mycotic infection can choose ketoconazole, chlamydia, mycoplasma infection can choose macrolides, such as azithromycin, roxithromycin, etc. After the inflammation is relieved, urinary symptoms will also improve. In addition, if there is urethral trauma, urethral tumors, stones, etc., which can also lead to urethral stricture or even obstruction, resulting in difficulty in urination or even inability to urinate, urethroscopy should be used to clarify the specific urethral disease and adopt appropriate methods of treatment; 3. Bladder diseases: such as neurogenic bladder, or long-term bladder outlet obstruction resulting in poor contraction of the bladder forcing muscle, etc., resulting in difficulty in urination. The treatment of this condition is more difficult, and medication can be taken. If medication is ineffective, clean catheterization or cystostomy can be used, and sacral nerve modulation (SNM) surgery can also be tried; 4. Psychological factors: When patients have panic and anxiety, the body is in a tense state, which leads to tensing of the urethral sphincter and contraction of the detrusor muscle, resulting in the problem of difficult urination. Should promptly relieve the bad mood, can improve the symptoms of difficult urination; 5, drug influence: such as antidepressants as well as some cold medicine will inhibit the parasympathetic nerve, leading to difficulty in urination. It is recommended to go to the hospital to check whether the difficulty in urination is caused by drug factors, and the doctor will determine whether the drug needs to be discontinued or replaced by drug treatment.