When giving injections to treat endometriosis or uterine fibroids, some patients and even some doctors are not sure when to give them? How to play? The side effects are not quite clear, now the answer is as follows: 1, within the second to fifth day of menstruation; if you take good contraceptive measures, you can also take the injection about ten days before your period; 2, every four weeks a shot (subject to the time of the first injection); 3, about half a month after the first injection there will be a vaginal bleeding, the amount is not much, but the time may be long; 4, half a month after the first injection stomach pain may Subcutaneous injection of Noradren (3.6mg/stem) or subcutaneous injection of Inhibiton (3.75mg/stem) or intramuscular injection of Daphylline (3.75mg/stem), a total of 3 – 6 injections. Change the injection site each time. Do not rub the injection site. A transient increase in blood estrogen levels may cause a transient increase in pain and breast tenderness within 2 weeks after administration. Subsequent side effects are mainly menopause-like symptoms caused by low estrogen, such as hot flashes, sweating, irritability, headache, insomnia, vaginal dryness, change in libido, depression, and breast reduction. Androgenic effects such as acne, increased skin oil, edema, hirsutism and voice changes are rare. It has been reported that it can cause rash, which is mostly mild and does not affect the treatment. Patients tend to be amenorrheic from the 2nd month after drug administration, and may have a small amount of drenching bleeding. Weight gain is not significant. There is generally no effect on blood lipids and liver function. Long-term use of the drug may cause bone calcium loss, but does not increase the risk of fracture, and can gradually recover after discontinuation of the drug. During the use of the drug, it is advisable to use instrumental contraception, and pregnancy should be discontinued immediately. Pregnancy should be attempted after the formal resumption of menstruation after discontinuation of the drug for those with fertility requirements. Generally, menstruation resumes about 3 months after discontinuation. If menopausal symptoms are more severe during the drug use, it is now recommended to start supplementing with small doses of estrogen and progestin from the second to third month of drug use, which is known as “add-back therapy”, such as taking premarin 0.3mg-0.625mg and This can prevent bone loss and reduce the side effects of low estrogen without reducing the efficacy of endometriosis. When these drugs are used for more than 6 months, it is necessary to perform “reverse add-on therapy”.