CA125 and CA199 are two of the tumor markers, of which CA125 is closely related to the occurrence of endometriosis and CA199 is closely related to the occurrence of digestive tract tumors. If a woman has progressive aggravation of dysmenorrhea, or ultrasound examination found pelvic mud-like echo mass, at the same time check the CA125 level is elevated, then we should be highly alert to the occurrence of endometriosis. And in patients with chronic pelvic inflammatory disease and pelvic effusion, elevated CA125 can also occur. CA199 is mainly related to the occurrence of digestive tract tumors, such as pancreatic tumors, rectal cancer, etc. It is also elevated in chronic pancreatitis, gallstones, cirrhosis and other diseases. For patients with elevated tumor markers, it is recommended to improve gynecological ultrasound, pelvic MRI, gastrointestinal microscopy, abdominal CT and other related examinations to clarify the cause of the disease and then actively treat it under the guidance of the doctor.