Usually, 5-hydroxytryptamine cannot treat premature ejaculation, and it is recommended to choose 5-hydroxytryptamine reuptake inhibitors such as dapoxetine for treatment under the guidance of a doctor. As 5-hydroxytryptamine belongs to the neurotransmitters, the main role is to regulate the mood and so on, but there is no role in the treatment of premature ejaculation, need to pay attention to. Clinical treatment of premature ejaculation is 5-hydroxytryptamine reuptake inhibitors, such as dapoxetine, sertraline and so on. These drugs can mainly inhibit the reuptake of 5-hydroxytryptamine in the central nervous system, increase its content, improve the ejaculatory control of the central nervous system, so as to have the effect of treating premature ejaculation. When using 5-hydroxytryptamine reuptake inhibitors it is important to note that it is not recommended if you are allergic to the drug or its ingredients. In addition, the drug needs to be contraindicated in the case of serious heart diseases such as severe heart failure, myocardial ischemia. The drug should be used in accordance with medical advice.