In many years of clinical work, we found that tumor patients are mostly accompanied by obvious emotional and mental disorders, mainly manifested in two types: one is the impatient type, extremely easy to get angry and anxious, extroverted performance; the other is the depressed type, superficially calm, internally thinking a lot, not enough communication with others, introverted performance. Both types can significantly promote the occurrence and development of tumor to different degrees and are closely related to the prognosis of patients. Therefore, the regulation of emotion is of great importance for patients’ recovery, among which the role of Chinese medicine in this area should be said to be very advantageous. Here is an article written by our group combined with our recent research for your reference! In recent years, the establishment of the biopsychosocial model of medicine has prompted scholars to pay attention to the role of social, environmental and psychological factors in the etiology of tumors. Among them, psychological factors, i.e. emotional factors, play an important role in the development of tumors. This article elaborates from the theoretical basis to the clinical application of the method of draining the liver and Qi in the treatment of tumors, in order to provide reference for clinical workers. The seven emotions are based on the functional activities of the internal organs. Too much or not enough of them will damage the function of the internal organs, and prominently manifest in the disturbance of the qi flow, thus participating in the occurrence, development and transformation of tumors. The seven emotions are based on the activities of the internal organs, and too much or too little of them will damage the internal organs’ functions, and prominently cause disorders of qi, thus participating in the occurrence, development and regression of tumors. In a large number of ancient texts, medical practitioners have recorded that internal injuries caused by emotion and will cause tumor due to obstruction of qi and disturbance of qi and blood, for example, “Nei Jing” says: “If you are suddenly hit by cold outside, if you are injured by worry and anger inside, the qi will be reversed …… and the blood will not be dispersed, and the fluid will be concubitated. Bo steep-jacketed swept away the shivering di cent fugue sheet wreckage dam bridge depression, accumulation of night and day, spleen qi dissipation obstruction, liver qi stagnation, then become hidden nucleus.” These all illustrate that long-term abnormal changes in the seven emotions can cause a loss of function of the internal organs, the lack of positive energy, external evil resides in it, resulting in the poor operation of qi and blood, stagnation of veins and channels, and become accumulation over time. Clinical practice proves that malignant tumor is a strong psychological stress for patients, and has its unique psychological characteristics, such as cognitive and emotional manifestations of depression, lack of interest, irritation, low self-evaluation or guilt, difficulty in concentration, suicidal thoughts and other clinical manifestations of depression, modern medicine has studied the connection between these clinical symptoms and tumor from the molecular biology level, and now it is believed that the mechanism of action is related to the neuro-endocrine-endocrine mechanism. The mechanism of action is believed to be related to the alteration of neuro-endocrine-immune regulatory network, psychological stress and pain stress, melatonin mechanism, retinoid nuclear receptor mechanism, cytokine mechanism and DNA damage and repair mechanism. The theoretical basis of liver and qi treatment 1. The liver is most closely related to the seven emotions that cause disease. For example, in Su Wen – Pain in the Body, it is said: “I know that all diseases are born from qi. Anger is gas on, happy is gas slow, sad is gas …… anger is gas reversal, even vomiting blood and food discharge”. And no matter what kind of emotional disorders, can eventually lead to disorders of the qi. The liver likes to be organized and is not depressed, the main drainage, the main blood collection. Liver Qi is the basis for the smooth flow of Qi in the five viscera and six bowels, the seven emotions are more anger, and anger is more likely to hurt the liver. If the emotions are not smooth, the anger is not stretched, and the desire is not fulfilled, resulting in liver qi stagnation, qi disorder, unfavorable lift and discharge, and abnormal drainage, not only the internal organs become diseased, but also affect other internal organs, causing a variety of symptoms, which is quite common in clinical practice; as Wang Mengying said, “the disease of the seven emotions must start from the liver”. Read the medical essays “said:” where the internal organs of the twelve channels of qi, all must be the liver and gallbladder to encourage the qi, to be able to regulate the smooth and not sick.” We believe that the method of draining the liver and Qi should be used as the basic method for the whole intervention of tumor treatment. We believe that the whole intervention of the method of draining the liver and Qi in tumor treatment can benefit patients to the greatest extent with other methods of treatment. A major feature of malignant tumor pathology is blockage and inaccessibility, and local blockage and inaccessibility will inevitably affect the operation of qi in the whole body. Qi is distributed in all parts of the body and its basic forms of movement are ascending, descending, exiting and entering, and when the movement of Qi is not normal, the pathological process of phlegm, dampness, stasis and heat will arise, which will further aggravate the poor operation of Qi, thus forming tumors in a vicious cycle. Clinically, qi disorders are often reflected in the internal organs based on the depression of liver qi, which then affects the movement of qi of spleen qi, lung qi, heart qi, kidney qi, stomach qi, etc. The dysfunction of qi of each internal organ produces a series of pathological changes such as blood stasis and phlegm, and various clinical symptoms or disease itself causes emotional and mental discomfort or even agitation and depression, which also affects the qi of the internal organs, and this process often accompanies the disease all the time. This process often accompanies the disease throughout. Qian Bo Wen also believes that the treatment of tumor should first pay attention to regulating qi, and considers it as the fundamental method of treating tumor, while regulating qi should first focus on draining liver and regulating qi. Therefore, it can be considered that draining the liver and Qi is one of the basic methods in treating tumors and should be involved in the whole process of tumor treatment. According to the etiology and pathogenesis of tumor, Chinese and Western medicine practitioners have, after more than 50 years of clinical practice, put forward the treatment rules and methods of supporting the root, softening and dispersing nodules, clearing heat and detoxifying, activating blood circulation and removing blood stasis, attacking poison with poison and dredging liver and qi. Therefore, clinically, we should appropriately apply the rule of draining liver and qi in combination with other treatment methods, and at the same time, on the basis of evidence-based treatment, we should “balance yin and yang and treat the whole body”, “clearly identify the symptoms and root causes and weigh the priorities”, and “help the righteous and dispel the toxins”. Under the guidance of the basic principles of “balance yin and yang, holistic treatment”, “identify the symptoms and root cause, weigh the urgency”, “support the righteousness and eliminate the evil, stage treatment”, “treat different diseases together, treat the same disease differently”, and other basic principles, focus on the combination of disease identification and evidence identification, the combination of the whole and the local, fully flexible and appropriate use of the currently known Under the guidance of the basic principles of “different diseases, same treatment, different treatment”, we focus on the combination of identification and diagnosis, and the combination of overall and local, and fully and flexibly apply the known treatment methods and rules to achieve the best individual treatment. For example, in cases of Qi stagnation and blood stasis, Curcuma longa, Sumac, Peach kernel, Safflower, Red peony, etc.; in cases of Qi stagnation and phlegm coagulation, Radix et Rhizoma ginseng, etc.; in cases of Qi stagnation and Qi deficiency, Radix et Rhizoma astragali, Radix prunus ginseng, etc. However, how to make various treatments justified and appropriate combination is one of the priorities of clinical research today, and clinical research units should be encouraged to actively carry out large sample RCT or partial RCT clinical research in order to provide strong clinical evidence for evidence-based medicine. Clinical Application of Liver Diversification and Qi Management Method Clinical practice has observed that cancer patients generally have emotional disorders, and those who have suffered major mental trauma and have been depressed and troubled or pessimistic, short-tempered and sentimental for a long time are prone to tumors, and many patients are in a depressed state and have serious depressive symptoms after the occurrence of tumors, which is also closely related to the recurrence and metastasis of tumors. Now we summarize that liver cancer, breast cancer, stomach cancer, lung cancer, etc. are clinically applied with the rule of draining liver and Qi. Liver cancer belongs to the categories of “accumulation”, “jaundice” and “dysmenorrhea” in Chinese medicine, and liver depression and spleen deficiency is a common type of liver cancer. Pan Minqiu conducted a statistical analysis of the frequency and ranking of 253 clinical papers on the treatment of mid- to late-stage primary liver cancer and found that patients with liver depression and qi stagnation accounted for 46.7% of the cases, which often manifested clinically as dysthymia, abdominal distension, loose stools, emaciation, swelling of the lower extremities or ascites, with a pale, fatty tongue with a white, greasy coating and a slippery pulse. Some scholars believe that deficiency of the spleen and depression of the liver is the basic pathogenesis of hepatocellular carcinoma, so the treatment should be based on dredging the liver and strengthening the spleen and regulating the qi flow, which is in line with the principle of “When we see the disease of the liver, we know that the liver transmits the spleen, so we should first strengthen the spleen. Medicinal uses: Qing Pi, Chai Hu, Yu Jin, Neem, Leech, Yuan Hu in vinegar, Nan Xing and Han Xia. Some scholars have also adopted the method of tonifying the liver and kidneys (Chai Hu, Guang Yu Jin, Chuan Xiong, Xiang Shen, Fructus Fructus, steamed cornelian, Chinese wolfberry, He Shou Wu, Sang Sang Sang, Xian Ling Spleen, Centipede, Licorice) according to the theory of “liver and kidney homologation” to treat 81 patients with significant improvement in clinical symptoms and immune function, thus achieving prolonged survival. Modern clinical research proves that the combination of chemical arterial infusion and interventional treatment with liver and spleen-boosting herbs can improve patients’ immediate and long-term outcomes, quality of life, immune function, blood coagulation status, clinical symptoms, improve immune function, protect liver function and bone marrow function, reduce AFP and improve survival rate. Gastric cancer belongs to the category of “stomach pain” and “regurgitation” in Chinese medicine. In analyzing the etiology and pathogenesis of gastric cancer, medical doctors have paid special attention to the influence of emotional factors on the operation of qi and blood and the function of internal organs. For example, Suwen – General Assessment of Deficiency and Actuality says: “The disease of violent worry is also caused by isolation and blockage, and the upper and lower levels are not accessible”. The medical Zong Jinjiană» regurgitation choking hiccups ” said: “regurgitation choking hiccups always blood depletion, gastric and epigastric dry haggard, …… most of the loss of qi and blood, and because of grief and anxiety, then the spleen and stomach damage, blood gradually depleted, depressed gas to produce phlegm, phlegm is plugged and different, gas is up and down, obstructing the road, diet difficult to choke all and become “In 1978, the first clinical evidence classification formulated by the Beijing Stomach Cancer Collaborative Group of the First National Stomach Cancer Academic Conference was liver-stomach disharmony, whose main symptoms were: distension and fullness of the stomach and epigastrium, pain at times, fleeing to the two sides, bitterness in the mouth and distress in the heart, belching and stale, little food or vomiting and regurgitation, thin yellow or thin white tongue coating, and thin pulse. Qian Bowen believes that Qi imbalance caused by Liver-Qi stagnation is an important pathological factor in gastric cancer, and points out that long-term emotional depression and Liver-Qi stagnation lead to Qi imbalance in the spleen and stomach throughout the early, middle and late stages of gastric cancer, which leads to a series of pathological changes such as blood stasis and phlegm coagulation, thus scholars believe that regulating Qi and unblocking the liver and Qi flow throughout the treatment of gastric cancer. In clinical practice, the commonly used formulas to regulate liver and qi include Prosperity San, Four Reverse San, Chai Hu Dredging Liver San, Xiang Su San, Yue Ju Wan, Liang Fu Wan, etc. In specific application, attention should be paid to the selection of common drugs introduced into liver meridian or spleen and stomach meridian, such as Citrus Aurantium, Chen Pi, Citron, Buddha’s Hand, Yu Jin, Pregnancy, Hop Huan Pi, Chai Hu, Chuan Hu, Yan Hu, Hou Pu, Citrus Aurantium, Daji Pi, Juxiang, Sha Ren, Xiang Shen, etc. Also, according to the condition and the hostages, appropriate combination with strengthening the spleen and regulating qi is required. In addition, according to the different conditions of the disease, the prescriptions should be used to strengthen the spleen and regulate the qi, clear heat and detoxify the toxin, activate blood circulation and remove blood stasis, resolve phlegm and soften hardness, and harmonize the stomach and eliminate food. Breast cancer is mostly described as “breast rock” in ancient literature, such as “Danxi Xinfa”, which says: “A woman’s depression and sorrow are accumulated over time. It is not painful but not itchy, and after ten years, the sore will be trapped, which is called breast rock.” According to the book of “The Authentic Book of Surgery”, “depression hurts the liver, thinking hurts the spleen, and the accumulation of thoughts in the heart, which cannot be achieved, causes the meridians to become gangrenous and nucleated”. Clinical manifestations of breast cancer often include breast lumps, swelling and pain, pain in the two hypochondria, irritability, dizziness, bitterness and dryness of the mouth and throat, thin white or thin yellow coating, and slippery pulse. The clinical use of drugs is often based on the basic pathogenesis of “stagnation of liver qi and deregulation of the flushing and the free flow of Qi”, with the addition and subtraction of Prosperity San, commonly used in the form of whole Guahu, Chaihu, Yujin, Atractylodes, Chenpi, Preparedness Zi and Angelica. In the clinical study, Xu Li et al. used Chinese herbal medicines with the effects of de-stressing the liver and Qi, activating blood circulation and removing blood stasis, and detoxifying cancer toxins to form a formula based on prolotherapy (Chai Hu, Radix Angelicae Sinensis, Bai Shao, Atractylodes Macrocephala, Poria, Radix et Rhizoma Polygonati, Coix Coix Coix seeds, Cyperus rotundus, Phyllostachys, Wang Bu Li Xing, Curcuma longa, etc.) in combination with the TE regimen to treat breast cancer, which was better than the TE regimen in terms of improving common clinical symptoms and Karlson’s score. The chemotherapy alone group. Wang Chengxin et al. demonstrated through experimental studies that sparing the liver and soothing the breast granules (Chai Hu, Angelica sinensis, Dan Shen, Astragalus membranaceus, Yan Huo, Seaweed, Wang Bu Li Xing) have significant toxic effects on MCF-7 breast cancer cells and their antimutagenic and antimitotic effects can also lead to DNA strand breakage, which can interfere with gene transcription and produce anticancer effects. 4.Thyroid tumor According to the ancient Chinese medical texts, thyroid cancer belongs to the category of stone gall in Chinese medicine. The thyroid tumor is located in the neck and its occurrence is not only due to internal injury of emotion and will, liver failure, blood stagnation, and loss of diet and water and soil, as stated in “Jisheng Fang”: “Gall tumors are mostly caused by uncontrolled joy and anger, excessive worry and thought, and become the disease. The circulation of qi and blood in a person always wants to be free of stagnation. The loss of regulating ease, qi and blood stagnation, for gall for tumor”. Miscellaneous disease source rhinoceros candle gall tumor: “Gall tumor, qi and blood stagnation, the number of years far away, gradually growing gradually larger evidence.” This shows that Qi imbalance leads to blood stagnation and phlegm clotting as an important factor in the development of this disease. Clinical symptoms often include depression, chest tightness, constipation, hard neck masses that do not move up and down with swallowing, enlargement of the masses in anger, dark red tongue, thin yellow fur, and thin string veins. The formula is often used: Seaweed Yuhu Tang or Tong Qi Dispersing Firmness Pill with addition and subtraction, and the drugs often used are seaweed, kombu, half asia, Chen Pi, Qing Pi, forsythia, Bayberry, Chuanxiong, Curcuma longa, Andrographis paniculata, Xia Ku Cao, etc. At present, the treatment of thyroid tumors is often based on the etiology and pathogenesis of the disease, and Ji Yunhai has achieved certain efficacy in treating 58 cases of thyroid adenoma with a self-designed Qi elimination soup (seaweed, kombu, raw oyster, sea floating stone, yellow medicinal herb, Xia Ku Cao, angelica, piercing nail, heliotrope shell, thick park, trigonella, curcuma, and mucuna pruriens). 5, lung cancer liver and lungs are the main organs regulating the movement of Qi in the body. The liver is responsible for ascending and the lung is responsible for descending. The liver ascends in order for the lung to descend and the lung descends in order for the liver to ascend. The lungs are responsible for breathing, the seven emotions are internal, the qi is regulated, the qi and blood are popular, and the internal organs are in harmony, so the two are related to the qi movement of the human body. The clinical treatment can often be combined with Chai Hu Shu Liver San and Blood Mansions and Blood Stasis Tang or Tao Hong Si Wu Tang with addition and subtraction. Zhang Shulin et al. have applied the method of qi relief (roasted Astragalus, Chai Hu, Qing Han Xia, Radix et Rhizoma Ginseng, Radix Aromaticus, Shen Qu, Psidium Guajava, Fishy Herb, Chuan Bai Mu, Cardamom, Chen Pi, etc.) to treat 42 cases of lung cancer, which showed certain advantages in improving clinical symptoms and prolonging survival 4. It has been proved in a large number of clinical practices that in the treatment of tumors, the proper use of liver-regulating drugs based on the basic principle of diagnosis and treatment can often lead to better clinical effects. Experimental studies have also proved that liver-regulating drugs have better effects in preventing tumor occurrence, improving body immunity, preventing tumor metastasis, regulating gene and protein expression, inducing apoptosis, inhibiting telomerase activity and inhibiting vascular endothelial growth factor.