Herpetic epidermolysis bullosa drug rash is one of the most serious types of drug rash dermatitis, the characteristics include acute onset, rapid onset and inflammatory condition, which requires timely and active treatment. Herpetic epidermolysis bullosa drug rash, also known as toxic epidermal necrolysis and laxity, the clinical manifestations of diffuse purplish or dark red patches, vesicles, pain, etc., the onset of the disease is acute, rapid progress. Some patients may also have internal organ damage, systemic toxicity symptoms are more serious, serious life-threatening. The occurrence of herpetic epidermolysis bullosa drug rash is mostly related to drugs, thus, in the treatment, the first step is to stop using the relevant allergy-causing drugs, and at the same time, give the appropriate drugs according to the situation, such as mupirocin ointment, dexamethasone, methylprednisolone and other medications for treatment. If necessary, plasma exchange is performed. Patients suffering from herpetic epidermolysis bullosa-type drug rash are advised to seek prompt medical attention and symptomatic treatment under the guidance of a doctor.