Old Wang is 60 years old and has had gout for more than 10 years, nearly a year eating the “gout spirit” purchased back from Hong Kong on behalf of others. Wang felt that “the effect is good” recently gout are not attacked, but let the old Wang unexpectedly, a few nights ago, he suddenly vomited blood and fainted, was rushed to the hospital by his family emergency rescue. The first thing you need to do is to get a good idea of what you are getting into. Why would stomach bleeding occur? The first thing you need to do is to get a good idea of what you are getting into. The old Wang said: “Because of the pain, did not go to the hospital to seriously look at this problem, has been eating this medicine. Although occasionally the stomach will be uncomfortable, but how did not expect this drug is at fault.” In fact, the main reason for the occurrence of gastric bleeding is the long-term use of drugs of unknown composition and dosage: claimed to be expensive Chinese medicine, but actually adulterated with hormonal painkillers. A look at its outer packaging: no formal manufacturer, no factory address, no drug regulatory license code. The food and drug supervision department tested its composition, the so-called more than thirty kinds of precious herbs, in fact, is mixed with painkillers (indomethacin), hormones (prednisone) these Western medicine ingredients. And these two drugs are the most common types of drugs that cause drug-related gastric bleeding. There are two main types of drugs that can easily damage the gastric mucosa Hormones The commonly referred to “hormones” are short for adrenocorticosteroids: the common ones are prednisone, dexamethasone, cortisone, and so on. These drugs reduce mucus secretion and promote gastric acid and pepsin secretion. Patients with hyperacidic gastritis, gastric and duodenal ulcer disease can be aggravated by the use of the above drugs, and in serious cases, gastric bleeding and perforation can occur. Therefore, when taking such drugs for a long time, they should try to be paired with some acid-suppressing drugs, such as omeprazole and esomeprazole. Generally speaking, the above drugs are prohibited during the acute and active phase of gastric disease. If the above drugs must be used during the stable and remission period of gastric disease, they should be taken after meals as much as possible to reduce the damage to the stomach caused by direct contact between the drug and the gastric mucosa during fasting. You can also take gastric mucosal protective agents, such as aluminum thioglycollate, before taking the medication. NSAIDs are the most common painkillers, including the familiar aspirin, indomethacin, ibuprofen, naproxen and so on. These drugs are widely used, from small common diseases such as fever and cold, headache and toothache, to the treatment of bone and joint diseases, rheumatoid arthritis and the prevention of cardiovascular and cerebrovascular complications. Especially in middle-aged and elderly patients, long-term oral administration of small doses of aspirin enteric soluble tablets for half a year or even a few years, the slight stimulation of the stomach and intestines, gradually accumulating, can easily cause acute gastric mucosal lesions, erosive bleeding gastritis, peptic ulcers, and even bleeding. The gastric mucous membrane damage caused by such drugs is mainly two things: one is the direct stimulating effect of the drug, more importantly, the absorption of the drug inhibits the activity of cyclooxygenase, the latter makes prostacyclin, prostaglandin and other hormones with gastric mucous membrane protective effect secretion is reduced. Reminder Patients suffering from peptic ulcer disease, gastric ulcer and other “stomach diseases” should not abuse antipyretic and analgesic drugs, and should be used under the guidance of a doctor, not to use some painkillers or products with pain relief effects of unknown ingredients. Because the original local mucous membrane lesions, the use of drugs will aggravate the mucous membrane lesions, inducing bleeding. In addition, elderly patients, especially those older than 70 years old, are often combined with arteriosclerosis and low vascular elasticity. The gastric mucosa repair ability decreases, causing bleeding is not easy to stop bleeding, more caution should be exercised. Those who need to take hormones or NSAIDs for a long time should be aware that these two types of drugs may have the side effect of gastric mucosal damage, and it is best to take them after meals, or take some acid suppressants or gastric mucosal protectors at the same time, and if stomach discomfort occurs, they should seek medical attention to adjust their treatment plan.