Systemic tendon pain needs to be diagnosed according to the specific location. For example, cervical spondylosis can cause pain and discomfort in the neck and shoulders, that is, the upper limbs; lumbar disc herniation can cause pain in the lumbar region and lower limbs; metabolically involved bone diseases such as osteoporosis can cause pain mainly in cancellous bones (mainly in the lumbar spine); rheumatoid arthritis can also cause pain in the bones and joints of the whole body. Therefore, to determine the cause of the pain in the muscles and bones of the whole body, relevant tests are needed to make a diagnosis. Firstly, blood tests such as rheumatology tests can be performed; secondly, bone quality tests such as bone density tests can be performed on the whole body. Finally, bone marrow aspiration can be performed to see if the disease is myeloproliferative. In addition to the relevant tests, some clinical manifestations are also important. For example, whether there is morning stiffness and how long it lasts, whether there is redness and swelling in the painful area, and whether the joints in the painful area are symmetrical. According to the clinical manifestations, combined with imaging and blood test results, the specific disease can usually be clarified. In conclusion, generalized bone pain is a wide range of description and cannot be clearly diagnosed, so it is recommended to seek medical attention for relevant examinations as soon as possible to avoid loss of treatment and misdiagnosis.