Treatment of severe necrotizing pancreatitis mainly includes intravenous rehydration, correction of electrolyte imbalance, fasting, gastrointestinal decompression, anti-infection, medication and surgery. 1. Intravenous rehydration and correction of electrolyte imbalance: in order to prevent shock and improve microcirculation, continuous intravenous rehydration and correction of electrolyte imbalance are needed. 2. Fasting and gastrointestinal decompression: Severe necrotizing pancreatitis requires absolute water fasting and gastrointestinal decompression to minimize irritation to the pancreas. 3. Anti-infection: when the disease is combined with bacterial infection, it is often a mixed infection of aerobic and anaerobic bacteria, and cefoperazone and metronidazole can be used. 4. Drug treatment: applying drugs to inhibit pancreatic enzyme and gastric acid to reduce the secretion of pancreatic enzyme, including growth inhibitor, octreotide, omeprazole and so on. 5. Surgical treatment: abscess formation around the pancreatic necrotic tissue, pancreatic pseudocyst, combined with shock, need further surgical treatment, such as pancreatic necrotic tissue removal. Severe necrotizing pancreatitis is more serious, should be standardized treatment under the guidance of the doctor, so as not to affect the condition. In addition, the above drugs should also be used under the guidance of a doctor.