Patients with thickened and uneven toenails may initially be considered to have thick nail disease, which can be treated through surgery. In addition, nail fungus can also appear this kind of performance, but this condition is more difficult to cure, it is recommended that patients appear related symptoms, promptly seek medical attention. A, thick nail disease: 1, etiology: thick nail disease can be divided into congenital thick nail disease and, and acquired thick nail disease, congenital thick nail disease is an autosomal dominant genetic disease, more rare. Acquired thick nail disease is related to infection, trauma to the nail bed nail plate and occupational stimulation and other factors; 2, clinical manifestations: the main clinical manifestations of finger (toe) nail hyperkeratosis thickening, nail dystrophy, can lead to patients appear toe nail thickening, bumpy symptoms. In addition, it can also be accompanied by palmoplantar hyperkeratosis, as well as wart-like damage on the elbows, knees, and calves. 3. Treatment: Patients can have their thick nails extracted, or opt for nail matrix and nail bed scraping, which usually has a good therapeutic effect, but neither can have a curative effect, and there is a certain chance of recurrence. The most common causative agent is Trichophyton rubrum, and nail fungus generally refers to all nail infections caused by fungi; 2. The nail plate and nail bed are separated; 3. Treatment: If the symptoms are mild or if you cannot tolerate oral medication, you can use topical medication such as cyproheptadine and amorolfine for treatment. Oral medications, such as terbinafine, itraconazole, fluconazole, etc., can also be used, but should be taken under the guidance of a doctor in a specific dosage and medication, to avoid adverse reactions from blind medication.