In the clinical treatment of acne, topical medications are often used, such as retinoic acid gel, adapalene gel, and tazorotene gel, which are collectively known as retinoids. Retinoids are a revolutionary class of drugs in the field of dermatology and can solve many skin problems. Here we introduce topical retinoids. Why can retinoic acid gels treat acne? Why can topical retinoids such as adapalene be used to treat acne? In order for a drug to treat a disease, it must be able to block or interfere with one or more aspects of the disease’s development. An important part of the pathogenesis of acne is the keratinization of the sebaceous ducts, which many people do not understand. For example, the calluses on the hands of working people are typical of keratinization. The sebaceous glands have ducts that drain oil to the surface of the skin. If the ducts become keratinized and hardened, the mouths of the ducts become narrower and the oil cannot be discharged, so sebum secretions are wrapped inside the sebaceous glands. In this excellent environment, the acne-causing Propionibacterium acnes can multiply and cause or aggravate the development of acne. Retinoids can target the keratinization of these cells, allowing the sebum products to be smoothly removed from the skin, thus improving or treating acne, which is one aspect of the treatment mechanism. Of course, retinoids can also target multiple aspects of acne pathogenesis, but anti-keratinization is certainly the primary mechanism, and other elements will not be developed here. What are the varieties of retinoid gels commonly used in clinical practice? As we have mentioned before, the main topical retinoids commonly used in clinical practice are: retinoic acid gel, adapalene gel, and tazarotene gel. Of course, since there can be many manufacturers producing drugs, there are also other specific trade names, and the ones we list here are all chemical names. Because the technology and process applied by different manufacturers may differ, but the main ingredients of the drug are the same. What types of acne can be treated with retinoic acid-based gels? Because retinoic acid-based topical creams can act on multiple parts of the acne pathogenesis, most types of acne can be treated with retinoic acid-based creams. There are some exceptions to this rule: if you are allergic to the cream, you should not use it; if your acne has become pus-filled or cystic, then topical retinoic acid creams may not work, but oral retinoic acid medication is more effective. What is the best way to use retinoic acid gel in the treatment of acne? One of the most important characteristics of retinoids is their “photosensitivity”, which means that they are sensitive to ultraviolet light. Therefore, we generally advocate the use of this drug at night. Many people want to know how to better, how to deal with various situations, we are here to briefly introduce. 1.Dot application? If it is only the acne stage, or the red bumps stage, you can point gadfly facsimile F boil and take care of the bumps in Laos contempt └嘣谑褂玫墓讨杏幸徊糠秩丝赡芑岢鱿制し小鞋 閤 蟶蟶 蟶 蟶 蟶 蟶 蟶 蟶 蟶 蟶 蟶 蟶 蟶 蟶 蟶 蟶 蟶 蟶 蟶 蟶 蟶 蟶 蟶 2 When to apply? We work with patients in the course of clinical work are accounted for at night with, that is, to reduce its occurrence of photoallergic reactions. In fact, some geeks and nerds can also use it during the day if they stay at home every day and don’t go out. Another point to point out is that indoor fluorescent light exposure is of no consequence, because our “electric stick” emits light that does not contain ultraviolet components. 3.How long do I need to apply it? How long does it take to see the effect? Generally speaking, the first three weeks is the intensive treatment phase, after three weeks, the dosage can be gradually reduced. For mild acne such as whiteheads and blackheads, the effect is usually more obvious in three weeks. Other more serious types of acne must be combined with other treatments such as oral medications, etc. The use of the cream alone is not very meaningful. 4.What are the adverse reactions? How to deal with adverse reactions? In the process of using retinoic acid creams, some side effects may occur such as redness, dry skin, itching, irritation and stinging/burning sensation. If these occur, do not panic, stop using the medication for three nights and use topical hydrating and anti-allergic skin care products, after three days, you can generally continue to use it and the symptoms of adverse reactions will gradually disappear.