1, rheumatoid arthritis: often manifested as joint swelling and pain, mostly symmetrical, morning stiffness, involving mainly small joints, can also be seen in the knee joint as the first manifestation. Xue Luan, Department of Rheumatology and Immunology, Shanghai Yueyang Hospital 2, dry syndrome: dry mouth, eating buns or cookies need to be served with water, tooth loss; dry eyes, reduced tears, dry eyes discomfort. Recurrent rash, or progressive dyspnea may appear. 3. Systemic lupus erythematosus: unexplained fever, arthralgia, arthritis, not accompanied by joint deformity; butterfly-shaped erythema on the face, aggravated by sun exposure; oral ulcers; muscle pain, muscle weakness; bruising of fingers (toes), obvious in winter; hair loss; lymph node enlargement; epilepsy or psychiatric symptoms; hemolytic anemia, proteinuria or tubular urine, etc. 4, inflammatory myopathy: progressive limb weakness, manifested by the inability to comb hair, difficulty in undressing, difficulty in standing after squatting, and pain in the muscles. 5, ankylosing spondylitis: hip pain, low back pain, neck pain, improve after activity, aggravated by cold, with heat pain reduction, accompanied by morning stiffness. 6, leukodystrophy: recurrent mouth ulcers, pubic ulcers, ophthalmia, abdominal pain and gastrointestinal bleeding in severe cases.