Pain not only makes patients suffer, but more importantly, it can cause obvious adverse effects on the organism and bring about various complications, some of which are serious and fatal, such as myocardial infarction, hypertension, cerebral hemorrhage, etc. 1, the impact on the cardiovascular system: pain stimulation can cause an increase in the release of hormones and active substances in the patient’s body, causing increased blood pressure, tachycardia and arrhythmia. For patients with coronary artery disease, it can lead to myocardial ischemia and even myocardial infarction. For patients with low heart function can cause congestive heart failure. 2, the impact on the respiratory system: chest and abdominal pain caused by increased muscle tone, can cause the patient’s respiratory system ventilation function decreased, so that patients occur hypoxia and carbon dioxide accumulation, prolonged increase in respiratory work can lead to respiratory failure. 3. Effects on immune mechanism of the body: The stress reaction caused by pain can lead to changes in immune system such as lymphocytosis, leukocytosis and reticuloendothelial system in a suppressed state, which can weaken the resistance of patients to germs and increase the incidence of infection and other complications. Tumor patients may suffer from metastasis or recurrence of tumor due to the decrease in the function and number of killer T cells in the body and other immune changes. 4. Effects on coagulation function: The effects of pain-induced stress on the coagulation function of muscles include enhancing the adhesion function of platelets and reducing the fibrinolytic ability, so that the body is in a hypercoagulable state, and patients with cardiovascular and cerebrovascular abnormalities may suffer from cerebral thrombosis or cardiovascular accidents. 5, the impact on endocrine function: pain can cause the release of a variety of hormones in the body, leading to hyperglycemia, protein and lipid catabolism enhanced, making the condition of diabetic patients worse. The increased release of endogenous catecholamines can make peripheral injury-receptive nerve endings more sensitive, putting patients in a bad cycle of catecholamine release pain. Pain stimulation can also cause patients to experience psychological changes such as fear, insomnia, and anxiety, which can seriously affect their normal interactions with others. Therefore, pain should be treated effectively, which can improve the quality of life of patients and avoid serious complications.