Sulfasalazine is increasingly being used for immunotherapy, and its side effects should not be ignored. 1. It is recommended to take it after meals or with sodium bicarbonate. Nausea, vomiting, upper abdominal discomfort or loss of appetite may occur if taken orally. 2.It is necessary to increase the amount of water drunk. Sulfasalazine has damage to the urinary system and can produce crystals once the sulfasalazine in urine is precipitated. 3.Do not take with methotrexate at the same time. Sulfonamides compete with methotrexate to bind to plasma proteins, making the free blood concentration increase. The two drugs are synergistic, it is recommended to interval half an hour. 4. Take the medication on time. Sulfasalazine reaches its peak blood concentration 3 to 5 hours after taking the drug, and the half-life of this drug is 6 to 17 hours. In order to keep the blood concentration in a constant range, it is necessary to take the medication on time. 5. Effects on the reproductive system. Sulfasalazine will affect sperm vitality with long-term use, which will lead to reversible infertility and can be restored after stopping the drug. 6.Regular check of urine. 7.Regularly check the blood routine. Patients with ankylosing spondylitis need long-term use of sulfasalazine to control the disease, and long-term use of the drug will appear hematologic reactions, long-term use of the drug will inhibit bone marrow hematopoietic cells. 8. Pregnant and lactating women should use caution or prohibit the use of the drug to avoid competition for plasma albumin and replacement of bilirubin, resulting in increased free bilirubin in the blood of newborns or premature infants leading to yellow pox, or free bilirubin entering the central nervous system leading to nuclear yellow pox. 9, allergic to sulfonamides, salicylic acid is prohibited.