Hypertension affects a large number of people, with an estimated number of more than 200 million patients in China. Studies have shown that people with normal blood pressure at age 50 have a 90% risk of eventually developing hypertension, and that sustained elevated blood pressure is a key factor in the morbidity and mortality of atherosclerotic cardiovascular disease. Hypertension promotes lipid-induced atherosclerosis, while lowering blood pressure delays this pathological process. The complex relationship between hypertension and atherosclerosis is compounded by the existence of interactions with other major risk factors that together promote the formation of coronary and other atherosclerotic arteries. Coronary heart disease is more dangerous and has become a leading cause of death. Men are more likely to develop coronary heart disease compared to women, and the risk of coronary heart disease in women with hypertension is 3.5 times higher than in those with normal blood pressure. Hypertension, as a major risk factor, can increase the risk of coronary heart disease and the likelihood of its sequelae. Therefore, controlling blood pressure is significant for patients with combined coronary heart disease, and it is also critical for the prevention of coronary heart disease in patients with hypertension. Controlling blood pressure to reduce the risk of coronary heart disease starts with lifestyle changes, which are the basis of all treatment. Patients will benefit significantly from quitting smoking and controlling blood glucose and lipids. It is now generally accepted that controlling blood pressure to a range of less than 130/80 mmHg and a diastolic blood pressure of no less than 60 mmHg is beneficial for patients with hypertension combined with coronary artery disease. Medication must be emphasized and adhered to. β-blockers, including commonly used drugs such as betalactam, are the drugs of choice for patients with hypertension combined with coronary artery disease because they not only have antihypertensive effects, but also have clear cardiovascular risk-reducing effects. When a combination of drugs is needed to control blood pressure, angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor antagonists (ARB) are the drugs of choice because they not only lower blood pressure, but also protect ventricular function. When the combination of two types of drugs does not achieve the target pressure control, two types of antihypertensive drugs, calcium antagonists and diuretics, can also be used. If we don’t achieve the standard, but discuss which drug is more suitable for patients with hypertension combined with coronary artery disease, we are putting the cart before the horse. Hypertension combined with coronary heart disease indicates that hypertension has already had target organ damage, and further development of the risk of life-threatening, should be given great attention. Frequent monitoring of blood pressure and strict control of blood pressure to meet the standard is the key to slowing down the progression of the disease, and is a gate that we should guard with the joint efforts of doctors and patients.