Patient: Numbness and pain in the fingers of the right hand at night while sleeping, (especially in the ring and middle fingers) but not during the day. The onset of the disease has been several years ago, and it occurs in the winter when the weather is cold. After driving a motorcycle for a long time during the day, my fingers would get numb but not painful, and they would not get numb after moving around. I don’t know what kind of disease I have, and I am very distressed. What kind of disease do I have and what kind of medicine can I take to get better? I had an MRI of the cervical spine last year and it was normal. Now I’ve just had an electromyogram, and it looks like peripheral neuropathy, so I’d like to ask the doctor to diagnose it and what medicine I can take. The actual numbness of the fingers that you mentioned: 1, clear check whether it is a single hand or another hand and feet have no signs, you can go to the neurology department to check, if electromyography has been confirmed to be peripheral neuropathy, but also to check some peripheral neuropathy susceptibility factors (such as blood sugar, etc.) is not present. Treatment is mainly nerve therapy, but local or systemic medication, according to the actual situation. 2, pay attention to the symptoms of the trigger such as cold or other circumstances, is not cold stimulation can be directly triggered, the finger color and other changes, to identify and Raynaud’s disease Patient: my blood sugar is not high, may have used a knitting machine, to pull the hand, since then the right fingertips began to tingle. It’s been almost ten years since then, but the condition used to be mild, only sometimes numb and sometimes not. Last year, after the birth of a child, the onset of the right fingertips more severe, numbness and pain, the past few days every day in the second half of the night are numb pain, the time are half an hour long, to sticky heaven and earth to pass. The left fingertips are also a little numb but not painful, and it’s good to move around a little, and the feet are normal. Patient: The color of my fingers is normal, and the numbness and pain occur in the winter in very cold weather, and I wake up in the middle of the night with pain, but my hands are fine in other seasons. I am afraid to touch cold things or lift heavy things. Doctor: Although you have performed electromyography, I think it still can’t exclude Raynaud’s disease, so we suggest you first keep warm to remove the cause of pain, in addition to strengthening neurotrophic treatment, in addition to vitamin B1 can add some B12 preparations such as adenosine cobalamin 1mg once daily intramuscular injection and other neurotrophic drugs.