Mammary gland hyperplasia is the most common breast disease in women, and its incidence accounts for the first place in breast diseases. In recent years, the incidence of this disease has been increasing year by year. Many patients visit the doctor because of breast discomfort and pain, but after treatment, they still do not get better or get better and worse. In adolescent or young women, breast pain may be swollen before menstruation, and sometimes the pain may spread to the back of the shoulder. Mastocytosis is a physiological hyperplasia of the normal breast lobules with incomplete replenishment and disruption of the normal structure of the breast, which is a pathological hyperplasia and is neither an inflammatory nor a tumor. It is a type of disease that is neither inflammatory nor tumor. It mostly occurs in women aged 30-50, with a peak incidence of 35-40 years old. The real cause of the disease is still unclear, at present, it is mostly thought to be related to endocrine disorders and mental and environmental factors. 1, endocrine disorders. The decrease of luteinizing hormone secretion and the relative increase of estrogen are the important reasons for the development of mastocytosis. Such as ovarian dysplasia, menstrual disorders, thyroid disease and liver dysfunction. 2, the influence of emotional and other mental factors. Mental tension, emotional excitement and other adverse mental factors tend to form mastocytosis, often stay up late, lack of sleep, etc. can also cause mastocytosis, and these adverse factors will also aggravate the existing symptoms of mastocytosis. 3, human factors or bad habits: women of advanced age, sexual dysfunction, abortion, marital discord, not breastfeeding and other reasons, resulting in the mammary glands can not have a normal, cyclical physiological activity. Wearing too tight bras or tight underwear, etc. 4, unreasonable diet structure, such as high-fat, high-energy diet resulting in excessive fat intake, drinking and smoking and other bad habits can induce mastopathy. In addition, now that people have a better diet, there are many people with high blood pressure and hyperglycemia, which also tend to make women have endocrine disorders, leading to mastopathy. 5, long-term use of estrogen-containing health products, birth control pills. Long-term excessive intake of estrogen will lead to endocrine imbalance, and some fast food, artificially raised aquatic products and poultry feed also contain hormones, which can also lead to the occurrence of mammary gland diseases. Clinical manifestations 1, breast pain: often swelling or stabbing pain, can involve one or both breasts, to one side is more common, the pain is severe can not be touched, and even affect daily life and work. Pain can be radiated to the ipsilateral armpit or back of the shoulder; some can be manifested as nipple pain or itching. Breast pain often appears or worsens a few days before menstruation, and after menstruation the pain is significantly reduced or disappears; pain can also fluctuate with emotional changes, exertion, and weather changes. This pain associated with the menstrual cycle and emotional changes is the main feature of the clinical manifestations of mastopathy. 2, breast lumps: lumps can occur unilaterally or bilaterally in the breast, single or multiple, generally preferably in the upper outer quadrant of the breast. They may appear as lamellae, nodules, or cords of different sizes, with lamellae being the most common. The borders are not obvious, the texture is medium or slightly hard, and there is no adhesion to the surrounding tissues, often with tenderness. Most breast lumps also have the characteristic of changing with the menstrual cycle, with the lumps increasing in size and hardening before menstruation and shrinking and softening after menstruation. 3, nipple overflow: a small number of patients can have nipple overflow, spontaneous overflow, mostly yellowish or pale milky white, there are also a few who can see overflow by squeezing the nipple. Caution is needed if there is bloody or coffee-colored overflow.