Many friends consulted, I hepatitis C antibody (anti-HCV) positive, very anxious to consult “doctor I antibody positive, is not a hepatitis C patients ah?” Important results first: “Hepatitis C antibody positive, does not necessarily mean that you are a hepatitis C patient ！！！！！” First of all, there are several possibilities for positive hepatitis C antibodies: 1, chronic hepatitis C, in this case hepatitis C virus RNA (HCV RNA) must be positive. 2, previous hepatitis C infection, spontaneous clearing occurred. In this case hepatitis C virus RNA (HCV RNA) is negative 3, some patients with hemodialysis and autoimmune diseases can have false positive anti-HCV. 4. One study found that more than 10% of the specimens with weakly positive antibodies detected by ELISA were false positive, but the viral load was negative. This may be the interference of other substances in the serum, or it may be a factor of operation. Only the first case belongs to patients with hepatitis C. What do we do if the hepatitis C antibody is positive? The important result comes first: “Review high-precision HCV RNA! Review high-precision HCV RNA! Review high-precision HCV RNA!” Quantitative HCV RNA testing is indicated for confirmation of current HCV infection, baseline viral load analysis prior to antiviral therapy, and response assessment during and after the completion of antiviral therapy. In pegylated interferon combined with ribavirin regimens, a highly sensitive HCV RNA assay can be used to more accurately identify RVR and thus provide a more reliable basis for determining the course of antiviral therapy. FAQ 1: I have a high level of hepatitis C antibody, is it more likely that I will be positive for HCV RNA? A: Yes. The higher the serum anti-HCV titer, the higher the likelihood of HCV RNA detection! 2. Does the fact that I am positive for hepatitis C antibody and negative for HCV RNA mean that I am immune to the hepatitis C virus and will not get infected in the future? A: No. Hepatitis C antibodies are not the same as hepatitis B antibodies and are not protective antibodies.