A few secrets of transaminases: 1. ALT is constantly fluctuating, even if close to 2 days, there can be 10-30% fluctuation, so for transaminases within 10% fluctuation can be considered no change, liver disease friends do not take ALT 10% range of fluctuations as an indicator of efficacy judgment, for example, 1 month ago to check transaminases 60U/L, now 54-66U/L range can be seen as No significant change in transaminases. 2, in a day ALT value is also physiological fluctuations, there are some foreign literature about the afternoon transaminases than early morning to 45% higher, so liver disease patients friends try not to afternoon blood test liver function ah, need to review liver function or try to come to the hospital early. 3, acute attack of hepatitis at the earliest stage, AST is rapidly rising, its peak is often greater than ALT, but 24-48 hours later, it shows ALT is greater than AST, this is because the half-life of ALT is up to 47 ± 10 hours, while the half-life of AST is only 17 ± 5 hours, so AST metabolism is fast, slow storage in the body, while ALT metabolism takes a long time, in the body soon a large number of more than AST. Therefore, patients who come to the clinic with acute illness usually have ALT greater than AST, and the ratio of ALT to AST will be discussed in the future. 4. Other factors that have an impact on ALT: gender, ALT is generally greater in men than in women; the higher the body mass index, triglyceride and total cholesterol levels, the higher the ALT level. And smoking, ageing, physical exercise is negatively correlated with ALT level. Seeing this, some smokers are very proud of themselves, thinking that smoking can lower transaminases! Don’t think so, other harmful effects of smoking are enough to shorten your life, smoking to lower aminotransferase is a very stupid behavior. 5, generally speaking, the higher the transaminase level, the more obvious the inflammatory damage to the liver, but when after a long period of chronic hepatitis developed into cirrhosis, the ALT level may not be high, or even normal, at this time can not be the number of transaminase to determine the inflammatory damage to the liver.