Modern minimally invasive interventional oncology is a comprehensive emerging discipline and an important part of comprehensive oncology treatment. It is a variety of treatment modes based on medical imaging, positioning and guiding by imaging equipment and technology, and integration of drug therapy, biology, gene technology and high-tech medical technology (such as radiofrequency ablation, microwave ablation, cryoablation, particle implantation, laser, high-intensity ultrasound focusing, etc.). It has the advantages of precise targeting of tumor positioning, small trauma, fast recovery, precise efficacy and reproducibility, etc. and has become the 4th major treatment method following the three traditional tumor treatments of surgery, radiotherapy and chemotherapy, and it is a constructive patient-oriented, humanized, rationalized, scientific, and individualized treatment model, which is a “biological-social-psychological” modern treatment model. It is a patient-oriented, rationalized, scientific and individualized constructive treatment mode, which is an individualized minimally invasive macro-targeted treatment under the guidance of the modern medical concept of “biological-social-psychological”. Minimally invasive interventional therapy for tumors is divided into vascular minimally invasive interventional therapy and non-vascular minimally invasive interventional therapy. The former involves selective or super-selective vascular cannulation through percutaneous vascular (mainly arterial) puncture, and catheters are placed into the target blood vessels to complete the treatments of tumors and tumor-related lesions, which mainly include transcatheter arterial infusion chemotherapy (TAI), transcatheter arterial embolization (TAE), and transcatheter arterial chemoembolization ( TACE); the latter mainly includes percutaneous tumor ablation therapy, radioactive particle implantation, and transcatheter drainage. According to the patient’s physical and mental conditions, the specific location of the tumor, pathological type, scope of invasion and tendency of development, combined with the changes in cellular molecular biology, the existing multidisciplinary and effective treatments should be applied in a planned and reasonable manner to achieve the best treatment effect at the most appropriate economic cost and improve the quality of life of the patients to the maximum extent, so as to achieve the personalized treatment for the patients with tumors. In view of the characteristics of tumor diseases, especially liver tumors, and based on the mechanism of tumor stem cells involved in tumor recurrence and metastasis as well as the relevant theories of changes in cellular molecular biology behavior, the concept of regional treatment combined with local treatment should be formed. Minimally invasive interventional therapy can directly inactivate the residual foci of tumors, including tumor stem cells, through minimally invasive treatment after tumor load shedding, for example, radiotherapy and chemotherapy, so that the tumor foci can be inactivated at the source and effectively prevent the tumor. It can inactivate tumor foci at source and effectively prevent tumor recurrence and metastasis. The personalized treatment of tumors is mainly multidisciplinary comprehensive systematic treatment. At present, the multidisciplinary comprehensive treatment of tumors based on minimally invasive treatment is mainly embodied in the following four major aspects: i. Minimally invasive ablation therapy combined with surgical treatment. ii. It is mostly used in the following cases: cases with large tumors that are not suitable for surgical resection in the first stage, cases with poor physical tolerance that cannot be operated and cases that refuse to be operated, and cases with residual recurrence or reoccurrence after operation. Minimally invasive ablation therapy combined with radiotherapy. Minimally invasive ablation therapy combined with chemotherapy. Minimally invasive ablation therapy combined with biological immunotherapy and molecular targeting therapy. Minimally invasive interventional therapy combined with sequential treatment. The effect of various minimally invasive treatments on tumor treatment will be affected by the size of the tumor, the different blood flow of the tissues and the relationship between the surrounding tissues and organs. With the continuous maturation and in-depth development of the discipline of minimally invasive treatment of tumors, the scope of minimally invasive treatment of tumors and its connotation have been further expanded and improved. Various minimally invasive therapies with different mechanisms and characteristics can improve the efficacy of tumor treatment through the sequential application of each other, and form a reasonable mode of combined sequential treatment, which can be comparable to traditional surgery in terms of the effect of killing tumors, and superior to surgery in terms of the protection of normal tissues and the protection of the immune function of the human body. The sequential combined mode of minimally invasive treatment for tumors, especially the organic combination of vascular minimally invasive interventional therapy and non-vascular minimally invasive interventional therapy, destroys and inactivates the tumor tissues through different mechanisms, which is a dual treatment of overall (regional) treatment at the level of the organ where the tumor is located and local intensive treatment at the level of the lesion, for example, the sequential combination of ablation therapy and biotherapy with TACE for primary liver cancer, which obviously improves the complete necrosis rate and reduces recurrent tumor death. complete necrosis rate, reducing the liver function damage caused by repeated TACE, and further improving the long-term therapeutic effect. With the continuous development of minimally invasive interventional therapy for tumors, minimally invasive interventional therapy is not only a palliative tumor treatment method, but also a sequential combined mode of minimally invasive therapy for certain tumors, which can achieve the goal of eradication, and achieve the efficacy comparable to that of some radical treatments for tumors.