First of all, I have been practicing medicine for more than 20 years and have removed numerous gallbladder patients, and I have not seen any case of colon cancer after cholecystectomy so far. Secondly, most of the patients who had their gallbladders removed must have biliary tract disorders, and patients with biliary tract disorders have poor metabolism of bile. It is inferred that the incidence of colon cancer is significantly higher in patients with biliary tract disorders due to the impairment of bile metabolism. Finally, in patients with gallbladder resection, with the removal of gallbladder, the common bile duct gradually exercises the function of gallbladder, and after the compensatory expansion of common bile duct, most of them have no clinical discomfort after adapting to the function of gallbladder.