The use of corticosteroids needs to be carried out under the guidance of a rheumatologist. In the acute and active stages of the disease, a full dose of glucocorticoids, even methylprednisolone, should be used, and after the disease stabilizes, the dose should be gradually reduced and a minimum maintenance dose should be found. Do not stop the drug suddenly to avoid “rebound” and aggravation of the disease. Indications for glucocorticoid therapy include: systemic lupus erythematosus, polyarteritis nodosa, aortitis, giant cell arteritis, leukoaraiosis, etc., mixed connective tissue disease, juvenile or adult Still’s disease, lipofuscinosis, rheumatic polymyalgia, as well as scleroderma and dry syndrome patients with visceral damage. Glucocorticoids should be used with caution in rheumatoid arthritis because they can only control the symptoms but not stop the progression of the disease, and long-term use can also cause side effects such as osteoporosis and femoral head necrosis. The dosage of glucocorticoids varies according to different diseases and their degree of activity, such as active lupus erythematosus, the usual dose is 40-60 mg of prednisone per day (0.5-1.0 mg per kg of body weight), and in severe cases, methylprednisolone is used for shock. Early morning doses can reduce the side effects of hormones. Rheumatic diseases, due to their inherent immune disorders, are prone to infections. Coupled with the long-term use of hormones, the defense function decreases, making it easier for various infections such as bacteria, tuberculosis and mycobacteria to occur, and infections are often one of the major causes of death in patients. Therefore, before glucocorticosteroid treatment, it is necessary to clarify whether the patient has potential infections, and generally the infection should be controlled before considering the use of hormones, but sometimes the patient’s condition is dangerous, and in order to save life, hormones can be used while actively fighting the infection and giving strong supportive treatment. At the early stage of rheumatism, the use of hormones can make the condition significantly better, and this effect is often excessively attractive, leading to the abuse of hormones, or because of the side effects of hormones and some people are afraid of them and do not adhere to the medication, both of these practices will bring harm to the treatment and aggravate the condition, so we hope that patients and doctors will cooperate, use the medication reasonably under the guidance of doctors, and master the timing of treatment to achieve the best results.