The causes of children crying in the middle of the night are broadly divided into non-pathological factors, such as hunger, thirst, too thick blankets, inappropriate temperature, and pathological factors, such as lack of vitamin D and calcium, intestinal obstruction, intussusception, etc., which need to be judged according to the baby’s state and accompanying symptoms, and if necessary, go to the hospital for consultation. I. Non-pathological factors: baby’s hunger, thirst, fright, wet diapers after urination or defecation, too high or too low room temperature, too thick blankets and mosquito bites, etc. may cause baby to cry in the middle of the night. Parents should look carefully for the causes of their children’s discomfort and help them solve the discomfort. Second, the pathological factors: 1, lack of vitamin D and calcium: If the baby’s body lacks vitamin D and calcium, there will be middle-of-the-night crying, a lot of sweating, twitching and other symptoms, you need to go to the hospital to check the body’s trace elements. If there is vitamin D or calcium deficiency, you should take vitamin D preparations or calcium supplements as prescribed by your doctor. Usually pay attention to take the child to outdoor sports, the right amount of light can supplement the body’s vitamin D and promote the absorption of calcium; 2, intestinal obstruction, intussusception: may appear abdominal pain, vomiting symptoms, intussusception can first follow medical advice to take non-surgical treatment, such as air enema, barium enema, in serious cases, surgical treatment is required. Intestinal obstruction requires fasting and water fasting, more surgical treatment; 3, other: baby crying in the middle of the night can not be relieved, but also need to go to the hospital for a comprehensive examination to exclude respiratory diseases, parasitic infections, intestinal torsion, acute appendicitis, acute cholecystitis, etc., according to the specific cause of treatment, mainly drug therapy as well as surgical treatment.