Nasopharyngeal cancer is one of the malignant tumors with relatively good prognosis. However, there are still some patients with tumor recurrence or residual after radiotherapy, which causes disease troubles to patients and clinicians, and even poor prognosis. For nasopharyngeal cancer recurrence and residual, the traditional treatment method is to increase the radiotherapy dose or wait for observation. Such treatment is very likely to cause serious radiotherapy injury, leaving sequelae such as facial muscle atrophy, difficulty in opening mouth or even facial deformity, or tumor spread due to delayed treatment and poor therapeutic effect. After our clinical practice, it is confirmed that radioactive particle implantation is a good method to treat recurrent residual nasopharyngeal cancer because it is directly implanted in the tumor with obvious killing effect, and at the same time, because it is a close irradiation, it has minimal impact on the surrounding normal tissues, so it has the advantages of reliable effect, small side effects and short treatment time. The specific treatment process: preoperative TPS is performed to carefully plan the treatment dose and scope; the lesion is localized under CT image guidance to determine the needle entry point, direction and depth. Then the 18G implantation needle is punctured into the tumor lesion in a stepwise manner under CT guidance. The radioactive particles were implanted after the position of the needle tip was verified to be correct. Since this is a minimally invasive procedure, only local anesthesia is used, which has few side effects and is easily tolerated by patients. It can be applied even to older and weaker patients. Radioactive particle implantation is a good method to treat recurrent residual nasopharyngeal cancer and provides new hope for patients with recurrent residual nasopharyngeal cancer.