Some thoughts on prehypertension in the elderly

  Pre-hypertension is the stage between normal blood pressure and hypertension. Several studies have shown that the incidence of prehypertension is high and the risk of cardiovascular morbidity is high, especially in the elderly who are in prehypertension with a high proportion of risk factors and complications. The clinical approach of Chinese medicine is to identify the symptoms of prehypertension, and to improve the prevention and treatment. The clinical use of TCM evidence-based interventions has the advantages of non-pharmaceutical interventions and western drug interventions, and its application prospects for the elderly with prehypertension need to be explored.  The concept of “prehypertension” was first introduced in the 2003 New Guidelines for the Prevention and Treatment of Hypertension in the United States (JNC7) [1], with a blood pressure range of 120-139/80-89 mmHg. In 2005, the Chinese guidelines for the prevention and treatment of hypertension [2] proposed a classification of normal high blood pressure, which is the same as the blood pressure range defined by JNC7 for prehypertension. 2007, the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC) working group jointly drafted a new version of the hypertension treatment guidelines [3]. These are the 2007 ESH/ESC guidelines for the management of hypertension. The new guidelines still retain the division between normal and normal high values between ideal blood pressure (<120/80 mmHg) and hypertension, i.e., normal blood pressure is 120-129/80-84 mmHg and normal high blood pressure is 130-139/85-89 mmHg. The proposal of pre-hypertension has caused a large reaction and much controversy in various aspects, but there is no denying that there is a transition zone between normal blood pressure and However, it is undeniable that there is a transition zone between normotension and hypertension, and shifting the defense line of hypertension to this zone to prevent the risk factors of cardiovascular diseases including hypertension will reduce the incidence, disability and mortality of hypertension.  2, intervention in the elderly pre-hypertension has important significance JNC7 proposed pre-hypertension according to: blood pressure in 120 ~ 139 / 80 ~ 89 mmHg individuals in the future risk of hypertension is twice as much as those whose blood pressure is at a lower level; 55 years of age is still normal blood pressure, the rest of life still has 90% chance of hypertension, blood pressure 115 / 75 ~ 185 / 115 mmHg, every 20 / 10 mmHg increase, the risk of cardiovascular disease. 10 mmHg, the risk of cardiovascular disease will increase by a factor of 1.  A growing number of studies have confirmed that blood pressure levels are continuously correlated with the risk of cardiovascular disease, and even if blood pressure is at a normal high value, it does not mean absolute safety and also increases the risk of cardiovascular disease. A 10-year follow-up survey of people aged 35-64 years in China [41] showed that the prevalence of high total cholesterol (TC), high triglycerides (TG), low high-density lipoprotein cholesterol (HDL-C), somatic obesity and abdominal obesity was higher in those with normal high blood pressure compared with those with normal blood pressure, with significant differences (P<0.001). After adjusting for age, sex, and TC, TG, HDL-C, glucose, waist circumference, and smoking, the 10-year risk of coronary events was 31% higher, the risk of stroke was 49% higher, and the risk of cardiovascular events was 44% higher in those with baseline blood pressure at high normal levels compared with those with normotension. Analysis of the blood pressure of 1892 elderly people who underwent health check-ups revealed that 13.4% had normal high blood pressure and that ST-T changes were significantly higher than in the normotensive group (P<0.01). On the other hand, it reflects the potential risk of cardiac damage in normotensive levels. Some scholars [6] have suggested that early prevention of cardiovascular disease risk factors is no longer enough to focus only on the control of hypertensive patients. Attention should also be paid to the abnormal metabolic changes in prehypertensive individuals. Only then can comprehensive prevention and treatment be achieved. This understanding should be said to have a greater clinical reference value.  In prehypertensive patients, there is a thickening of the carotid intima-media and an increase in atheromatous plaque, and the increased pressure and greater blood flow impact accelerates arterial compliance and vascular remodeling. Such changes undoubtedly increase the chance of stroke [7]. The basic pathological change in the development of cardiovascular disease is atherosclerosis, and the early change in atherosclerosis is a decrease in arterial elasticity, and this decrease in elasticity will certainly promote the process of hypertension, which in turn promotes the risk of cardiovascular disease, thus creating a vicious circle [8]. In addition, it has been shown [9] that the level of C-reactive protein increases gradually along with the increase in blood pressure, and the presence of such an inflammatory response state inevitably promotes the interaction between atherosclerosis and hypertension and leads to endothelial dysfunction, which increases the incidence of cardiovascular disease.  In conclusion, prehypertensive people are at high risk of developing hypertension, and the incidence is higher in the elderly, whose presence of multiple risk factors promotes the occurrence of potential target organ damage. With the increasing incidence of hypertension in the elderly in China, its characteristics such as obvious blood pressure fluctuations, large pulse pressure, high incidence of target organ damage, and difficulty in lowering blood pressure have seriously affected the quality of life of the elderly, and prehypertension is already in a subhealthy state, which can cause physical discomfort and affect people's good psychosocial adaptation. Therefore, the implementation of effective interventions for the elderly with prehypertension is also the embodiment of the concept of treating the disease, which is important for improving the quality of life and reducing the incidence of hypertension and cardio-cerebral vascular disease.  3.1 There is a significant lack of compliance with non-pharmacological interventions for prehypertension The prevention and treatment of prehypertension in the elderly cannot be ignored, and the significance of non-pharmacological treatment, mainly lifestyle improvement, has been recognized. The following interventions were used in the experimental group: elimination of various factors causing blood pressure rise and concurrent diseases; lifestyle changes, reasonable diet, weight control, smoking cessation, alcohol restriction, salt restriction; appropriate exercise, maintaining an optimistic attitude; health education; care and love for patients, guidance of home care, and spiritual support. The results found that there were significant differences in blood pressure decrease and weight loss in the test group before and after the test (P