1. What factors are associated with the development of acne? The occurrence of acne is closely related to many factors such as excessive sebum secretion, follicular sebaceous duct obstruction, bacterial infection and inflammatory reaction. In addition to the above factors, the occurrence of acne in some patients is also related to the immune function of the body, especially in some special acne such as acne conglobata and acne fulminans, where the immune response plays an important role. 2.What are the manifestations of acne? Acne can manifest itself as blackheads, whiteheads, inflammatory papules, pustules, nodules, cysts, etc. After acne heals, it is easy to cause pigmentation, i.e., acne marks, enlarged pores and even scar-like damage, which affects beauty or even disfigures the face. 3.Grading of acne: According to the severity of the lesions, there are 3 degrees and 4 grades. Grade 1 (mild): acne only Grade 2 (moderate): acne + inflammatory papules Grade 3 (moderate): acne + inflammatory papules + pustules Grade 4 (severe): acne + inflammatory papules + pustules + nodules, cysts or scarring 4.How should acne be treated? Mild acne: Eliminate acne and reduce sebum. Topical anti-keratinizing drugs + fruit acid treatment. Moderate acne: Eliminate acne, reduce sebum, and anti-inflammatory. Oral or topical anti-keratinizing, anti-inflammatory medication + fruit acids treatment. Severe: oral anti-inflammatory and anti-keratinizing medication + red and blue light. Acne marks, scarring: fruit acid treatment + photon or fractional laser.