The treatment of papular urticaria with large blisters includes general treatment, systemic medication, localized treatment and fluid extraction. 1. General treatment: patients should avoid scratching to avoid infection after scratching. 2. Systemic medication: oral antihistamine such as benadryl and cetirizine. 3. Localized treatment: Itch-relieving lotions such as phenol-containing glycerite lotion can be used externally, or corticosteroid creams can be used externally. When secondary infection occurs, antibacterial drugs should be applied, such as mupirocin ointment. 4. Fluid extraction treatment: Serious cases need to seek medical attention to have the blister fluid extracted. When patients with papular urticaria have blisters, they should not use their own medication, but should go to the hospital in time, and standardize the treatment under the guidance of the doctor.