Mammary gland hyperplasia belongs to the category of “breast fetish” in Chinese medicine, and its occurrence is closely related to the menstrual cycle. The source of the disease lies in kidney deficiency, while liver qi stagnation, spleen loss of health, qi stagnation, blood stasis, phlegm coagulation is also the standard of the disease. Chinese medicine from a holistic concept, recognizing that breast disease is a local manifestation of the overall imbalance of the human body, “the cure must be sought at the root”, the use of kidney tonification method to regulate the overall internal organs and meridians qi and blood, which can play a significant therapeutic effect. The occurrence of mastopathy is related to the poor luteal function of the ovaries after ovulation and the relatively low level of progesterone (P) secretion, resulting in a relative increase in estrogen and a higher estrogen/progesterone ratio. The endocrine function of the ovaries is directly regulated by the hypothalamus-pituitary-ovarian axis in women, and both the breast and the uterus belong to the effector organs of the female reproductive endocrine axis. In clinical practice, for menstrual disorders caused by abnormal function of the uterus, the recognized effective treatment is the method of tonifying the kidney and regulating the week, which can regulate the function of the hypothalamus-pituitary-ovarian axis, thereby regulating the level of sex hormones and adjusting menstrual disorders, infertility and other diseases. Mastocytosis is also an effector organ lesion caused by the dysfunction of the female reproductive-endocrine axis, and its symptoms are closely related to the menstrual cycle, manifesting as periodic breast pain that accompanies the menstrual cycle, and patients are accompanied by emotional abnormalities, insomnia, constipation and other discomforts. According to Chinese medicine, the origin of the disease lies in the deficiency of essence and blood in the kidneys, and the imbalance of the flush and the spleen, followed by the loss of drainage in the liver and the loss of health in the spleen, resulting in the unfavorable transformation of yin and yang, resulting in breast lumps, swelling or pain, and periodic episodes, accompanied by low menstrual volume or lumps, lumbago and weakness; anxiety and depression due to liver qi stagnation and emotional disorders; insomnia and sleeplessness due to the lack of yin and blood and the loss of nourishment for the soul; constipation or bowel movement due to the lack of health in the spleen and the loss of harmony in the stomach. If the spleen is not healthy and the stomach is not in harmony, constipation or poor bowel movement will occur. Therefore, in the treatment of mastocytosis using the method of tonifying the kidney and regulating the week, the postmenstrual follicular phase is characterized by a deficiency of blood and kidney yin, so it is important to nourish kidney yin, regulate liver and blood, increase the levels of luteinizing hormone (LH) and estradiol (E2), and induce feedback from the pituitary gland. It can also reduce the conversion of androgens to estrogen, which can significantly improve the symptoms of cyclic breast pain and significantly reduce the size of hyperplastic lumps, as well as have a significant effect on the patient’s accompanying symptoms such as irregular menstruation, anxiety and depression, insomnia, constipation or dyspareunia.