Calcification is a pathological change formed by the deposition of calcium within a fibrotic lesion during the progression of the disease. Calcification is commonly seen in tuberculosis and chronic infectious diseases. Calcified lesions usually appear as strong echogenic or dense images similar to stones on ultrasound or CT images. Calcified foci in the liver are foci formed by abnormal deposition of calcium in liver tissue cells due to liver disease, and most of these foci are formed during the healing process of the disease. Most patients with calcified foci are found during physical examinations, and most intrahepatic calcifications have no specific clinical manifestations or only show symptoms of the primary disease. The presence of intrahepatic calcification foci should be actively examined to determine the primary disease and then treated accordingly. Therefore, the discovery of intrahepatic calcification foci should not be a cause of blind fear and terror, but should first be actively examined to exclude primary or secondary liver tumors, and at the same time pay attention to distinguish liver infection and inflammation, and go to regular hepatobiliary surgery or general surgery for treatment, only when the cause of calcification is clear can the correct targeted treatment be taken.