1. What is the autonomic nerve The autonomic nerve, also known as the visceral nerve, mainly includes the sympathetic nerve and the parasympathetic nerve. They mainly regulate the state of the body by sensing the internal and external environment (e.g. external climatic and environmental factors and internal mental and psychological states). Autonomic nerves are not subject to volitional control throughout the body, but are more widely distributed in the glands and visceral organs, and play a major role in regulating the function, physiology, and pathology of these parts. Autonomic nerves regulate the whole body and are involved in the occurrence and development of almost all diseases, and tumors are no exception. 2. Clinical manifestations of autonomic nerves associated with malignant tumors 1) The most favorable parts of tumors are located in glands (breast, thyroid, etc.) and internal organs (lung, liver, stomach, intestines, etc.), and the functional activities of these parts are dominated by autonomic nerves of human body. 2) There are similarities between patients with tumors, and the autonomic nerves are mainly involved in regulating the functions and physiology of these parts. 2) There are similar symptoms of autonomic nerve or excitation or inhibition among tumor patients, for example, most breast cancer patients have symptoms of sympathetic nerve excitation such as fatigue, sweating, dry mouth, poor appetite, poor sleep and so on. 3) There is a certain correlation between the metastatic site of the tumor and the autonomic innervation of the primary site. Most of the tumor metastatic sites are in bone, brain, liver, lung, etc. These sites are mainly subject to sympathetic innervation. And these sites are mainly innervated by sympathetic nerves, and the damage of these sites is often aggravated when the sympathetic nerves are abnormal. This may be a direct cause of tumor metastasis. (4) It is known that the emotions and mentality of tumor patients have obvious influence on the disease, and these emotions and mentality are directly related to the state of autonomic nerves, which can be obviously controlled by regulating the autonomic nerves. Modern medical research evidence on the correlation between autonomic nerves and malignant tumors In recent years, some international authoritative medical journals have published the latest discoveries of many scientists on the relationship between malignant tumors and autonomic nerves: the sympathetic nerve distribution density of patients with longer survival period in gastric cancer is higher than that of those with shorter survival period, and the regulation of vagus nerves has a positive significance on the survival period of patients in esophageal cancer. In colon cancer, the cancer cells themselves can secrete acetylcholine (ACH), which in turn stimulates the rapid growth of intestinal cancer cells, so the inhibition of the secretion of acetylcholine is of great significance in the treatment of intestinal cancer. Similarly this autocrine loop plays a role in lung cancer. Abnormal sympathetic excitability can induce metastatic events in breast cancer, and it has been found that by inhibiting sympathetic excitability the occurrence of breast cancer strand metastasis can be delayed. In liver cancer, sympathetic excitability can exacerbate liver damage. In 2013, the American Journal of Science authoritatively released the results of Claire Magnon et al.’s study on prostate: the distribution density of sympathetic or parasympathetic nerve fibers in tumor tissues and tissues of high-risk groups increases, and this specific nerve distribution has a close relationship with the degree of malignancy of the tumor and the high or low recurrence rate. In animal experiments, after treating autonomic nerves in a certain way, the growth of tumors was obviously inhibited. 4. The significance of regulating the autonomic state for tumor patients 1), prolonging the survival period. The starting point of this study is to directly target the survival period of patients, which is the result of comparing the patients with longer survival period and shorter survival period and discovering the regularity therefrom, which is clear and objective. Improving the autonomic state in a favorable direction will objectively prolong the survival period. 2) Preventing or delaying tumor recurrence and metastasis. The autonomic state is closely related to the metastasis of the tumor, and tests have confirmed that improving the autonomic state in some tumors can significantly inhibit the occurrence of metastatic events. (3) Indirectly shrinking the tumor. This method mainly regulates the internal environment of the body, creates an environment unfavorable to the growth of the tumor, and thus shrinks the tumor, but does not kill the tumor directly, so it is more effective to carry out this method together with surgery, radiotherapy and chemotherapy at the same time. 4) Improve the living condition of tumor patients. Adjusting the autonomic nerve can effectively improve the living condition of patients and relieve many symptoms. Measurement methods of autonomic state 1) Determination of autonomic labeling protein in tumor tissues 2) Heart rate variability analysis (HRV), skin sympathetic response (SSR), etc. 3) Observation and analysis of autonomic-related symptoms 4) Comprehensive analysis of related indexes in the blood. 6. Treatment modes and methods 1) Pharmacological treatment for regulating autonomic nerves. These drugs have been used in the clinic for many years and are safe and stable. According to the results of the above measurements, the relevant drugs should be selected for treatment. (2) Treatment with traditional Chinese medicine (TCM). Traditional Chinese medicine has obvious advantages in regulating the autonomic nerves, and its miraculous therapeutic effect is mainly exerted through the regulation of the autonomic nerves. Its treatment methods mainly include: internal and external application of traditional Chinese medicine, acupuncture and moxibustion, fumigation with traditional Chinese medicine, acupoint injection, ear acupuncture and so on. (3) Regulation of diet, living, emotion and psychology The regulation of daily life is also very important to the autonomic state of tumor patients. By regulating the rhythm of life and mentality, the autonomic state can be restored to normal, so that the physical state can be optimized to take advantage of the recovery of the disease. (4) Exercise especially for the ligaments and fascia related to the distribution of autonomic nerves can play an important role. (5), the choice of health care products Pharmacological studies have shown that some health care products have a certain effect on autonomic regulation, such as Cordyceps sinensis, sea cucumber, fish oil and so on. 5, other considerations When other treatments are ineffective, you may want to try this line of thinking from the autonomic perspective of individualized, meticulous and objective adjustment therapy, I believe there will be a good harvest. What is in line with science is truly effective.