1.Blood image check: observation should be strengthened during and after chemotherapy, and blood image should be checked generally 2-3 days after the end of chemotherapy; when leukocytes or neutrophils are found to be reduced to grade 3 or below, the blood image should be understood in a timely and dynamic manner, and blood image should be checked daily if necessary. 2. Discontinuation of leukopenia drugs: When leukocytes or neutrophils are reduced to grade 3 or above, discontinue chemotherapy or various drugs and treatments that may cause granulocyte deficiency. 3.Use of leukocyte-raising drugs: for leukocyte or neutrophil reduction up to grade 1-2, use oral leukocyte-raising drugs routinely; for leukocyte or neutrophil reduction up to grade 3 or above, use colony-stimulating factor (G-CSF or GM-CSF) 100μg-150μg, qd-bid, and decide the dose and time of use according to the condition. 4.Antibiotic use: For leukocyte or neutrophil reduction of three levels or more, broad-spectrum antibiotics should be used routinely to prevent secondary infection; if there is a combination of infection, active treatment should be given, early use of a sufficient amount of sensitive antibiotics, and if the fever does not subside in 3 to 5 days, it is appropriate to switch to another group or make corresponding adjustments according to the drug sensitivity results; pay attention to identifying whether there is a combination of fungal infection, and take corresponding measures. 5.Adrenocorticosteroid use: For granulocyte deficiency, apply adrenocorticosteroid, routinely using hydrocortisone 100mg-200mg/d, intravenously. 6, supportive treatment: in cases of severe infection or weakness, intravenous infusion of gammaglobulin, albumin, plasma, etc.; 7, Chinese medicine treatment: chemotherapy-induced leukopenia, clinically most of them are deficient in spleen and kidney, and deficient in yin and yang qi and blood, Chinese medicine soup treatment should be based on the treatment principle of strengthening the spleen and kidney, tonifying qi and blood. Astragalus injection, Angelica injection 2ml, foot Sanli point injection; Turtle and Deer Erxian Gum Babu agent Shenqui point external application; Chinese medicine tonic injection intravenous use can elevate white blood cells. When the external evil is repeatedly felt, the identification of evidence is combined with the identification of disease. When the evil is strong and the positive is weak, “treat the symptoms urgently”, “treat the root slowly”, or attack and tonic at the same time, or attack first and then tonic. According to the evidence, it should be pungent and warm, or pungent and cool, or clear heat and detoxify the infection. Chicken blood vine, astragalus, chasteberry, Xianmao, Xianling spleen, Cornus officinalis, deer antler herb, etc. can be reused to elevate white blood cells. The clinical use of drugs should be calm, if the kidney yang when warm but not dry, if nourishing the kidney yin is moist but not greasy; not too much use of pungent and hot cooked sapodilla, cinnamon, to prevent robbing the essence of the kidney blood; also not too much use of deer horn gum, tortoise shell gum products, to avoid hindering the kidney yang to warm the spleen and earth, in vain to increase the risk of fullness and stagnation. 8, care: once the granulocytopenia or lack of, it is appropriate to disinfect the patient, isolation, keep the oral cavity, five senses, skin mucous membrane, genitourinary tract, perianal and other places clean and hygienic, brush teeth, rinse mouth after meals, rinse the perianal area after defecation, diligent bathing, prevent infection. 9, diet: light, nutritious, easy to digest diet, avoid fatty, sweet and greasy; mouth ulcers or diarrhea, the use of liquid or semi-liquid is appropriate. Caution: 1. If patients have sudden chills, high fever, headache and general drowsiness during or after chemotherapy, they may have leukopenia secondary to infection and should have their blood checked to exclude it; for ulcers on mucous membranes such as the pharynx, gums and cheeks or severe diarrhea of unknown origin, accompanied by obvious symptoms of yin deficiency such as red and vivid tongue and flushed cheeks, great attention should be paid to the presence of leukocyte or neutrophil reduction The possibility of grade 3 or above. 2. For diarrhea with leukopenia, conventional antidiarrheal drugs such as flavopiridol are not effective, so it is not recommended to use Emmenthal; it is recommended to use gastrointestinal mucosal protective agents and growth inhibitors if necessary. For oral ulcers, topical preparations of growth factors can be used to promote ulcer repair. 3, the use of cell colony-stimulating factor (G-CSF or GM-CSF), there may be differences between the two phases of leukocyte release and bone marrow growth, the time of cell colony-stimulating factor use should be extended appropriately. 4. When leukopenia exists, there is a rapid decrease in leukocytes for a short period of time, and one should not be bound to the existing blood report and review the blood picture whenever necessary.