Most sleep apnea is classified as obstructive sleep apnea (OSAS). Anesthesia in OSAS patients is challenging because of the complex effects of anesthetic drugs on an already dysfunctional respiratory system and because OSAS patients often have severe co-morbidities [38]. Many anesthetic drugs can cause overreaction in patients with OSAS. Thiopental sodium, isoproterenol, opioids, tranquilizers, and laughing gas can decrease the tone of the muscle tissue that keeps the airway open [39]. The respiratory system of children with OSAS under halothane anesthesia has reduced responsiveness to carbon dioxide. Children with OSAS who were intubated and retained spontaneous breathing inhaled volatile anesthetic gases had lower ventilation than normal weight children and had a 50% incidence of apnea after administration of static fentanyl at 0.5 µg/kg. It can be inferred that the incidence of postoperative apnea is increased in OSAS patients, and therefore short-acting anesthetic drugs should be used whenever possible. Regardless of the choice of anesthesia, airway management should be enhanced to prevent airway obstruction and apnea-induced hypoxemia. When patients undergoing surgery under local anesthesia receive sedation, it should be administered slowly, as sedation decreases the amount of voluntary ventilation in patients with OSAS [42]. The incidence of respiratory obstruction may be reduced in the lateral position where the patient has a larger cross-sectional area of the pharynx than in the supine position. Adequate oxygenation should be performed before general anesthesia intubation and other emergency airways such as laryngeal masks should be prepared. Volatile gases or intravenous drugs may be chosen for maintenance of general anesthesia, but short-acting drugs are strongly recommended to shorten the duration of postoperative respiratory depression. Extubation should be performed after the patient is fully awake and spontaneous respiration has fully recovered. Postoperative analgesia should be part of a well-established anesthetic, but there is no feasible postoperative analgesic protocol for patients with OSAS. cases of respiratory depression during postoperative use of intravenous analgesia or epidural analgesia in patients with OSAS have been reported. Non-steroidal anti-inflammatory analgesics, local anesthetic infiltration of the postoperative wound, and peripheral nerve blocks used appropriately can reduce the amount of postoperative narcotic analgesia.