The human heart is like an engine. Through the constant contraction and diastolic movement of the heart, blood rich in oxygen and nutrients is delivered to the tissues and organs of the body. Various heart diseases will eventually damage the diastolic function of the heart, resulting in a decrease in myocardial contractility, cardiac output can not meet the body’s metabolic needs, then heart failure (heart failure) will occur. Heart failure is the end stage of the development of cardiac insufficiency caused by various heart diseases, and once heart failure occurs, most patients step into a process of progressive deterioration. Epidemiologic data show that the prevalence of heart failure in adults in China is 0.9%, with about 4 million patients nationwide. The mortality rate of heart failure is also high, with a 5-year survival rate similar to that of malignant tumors. Half of the diagnosed heart failure patients will die within 4 years, and the 1-year mortality rate of patients with severe heart failure is as high as 50%. Due to its high morbidity and mortality rate, it has now become a worldwide problem with serious health hazards. What are the clinical manifestations of heart failure? Symptoms of heart failure are on the one hand related to the reduced ejection capacity of the heart, such as chest tightness and shortness of breath after activity, coughing and phlegm, easy fatigue, and reduced exercise endurance. On the other hand, due to the reduced cardiac function, the heart can not effectively eject blood, resulting in systemic blood reflux obstacles, blood stagnation in the systemic tissues and organs, appearing in the gastrointestinal tract, liver and kidney stagnation of the performance, such as epigastric fullness, nausea, vomiting, loss of appetite, decreased urinary output, nocturia, and so on, and in severe cases, lower limbs and even the whole body may be swollen. Heart failure has different conditions and clinical manifestations. Especially the elderly due to the organs of the body system gradually aging, functional decline, slow nerve response, coupled with a variety of diseases coexist, a variety of diseases interfere with each other, so that the symptoms of heart failure is not obvious, some are very easy to confuse with the symptoms of other diseases. Especially in the early stage of heart failure, some elderly patients do not even have any symptoms or only have a sense of fatigue. Cardiac Resynchronization Therapy – Effective Treatments for Heart Failure Over the past 30 years, there has been tremendous progress in the treatment of heart failure. However, the current main treatment is still based on drugs, including the application of cardiotonic, diuretic and vasodilator drugs as well as drugs that antagonize neuroendocrine overactivation, in order to reduce the heart’s preload and afterload and to increase the heart’s contractility. Although the application of drugs can alleviate the symptoms, there are still a considerable number of patients who cannot change the progressive aggravation of heart failure and improve the prognosis even with optimal drug treatment. The emergence of cardiac resynchronization therapy has opened up new avenues for the treatment of congestive heart failure, showing hope. What is cardiac resynchronization therapy? Clinical work found that a considerable portion of patients with moderate to severe heart failure cardiac movement asynchrony phenomenon, which is like more people rowing a boat, everyone rowing in unison will get twice the result with half the effort, and each for their own, each other out of sync when the boat can not move forward quickly, or even the original place to beat around the corner. In heart failure, the heart moves out of sync, including atrial and ventricular asynchrony, right and left ventricular asynchrony, and left ventricular asynchrony. Cardiac resynchronization therapy restores synchronization of the atrial and ventricular motions of the heart by sequentially agitating the atria and left and right ventricles through the implantation of electrodes in the right atrium, right ventricle, and left ventricle, respectively (via the epicardial route). A series of clinical trials have confirmed that cardiac resynchronization therapy not only relieves heart failure symptoms and improves patients’ quality of life, but also reduces mortality and hospitalization rates, and changes the course and prognosis of heart failure patients, which has brought new hope for the treatment of patients with moderate-to-severe heart failure. At present, cardiac resynchronization therapy has become the first-line treatment for patients with moderate-to-severe heart failure accompanied by ventricular motion dyssynchrony. In China, due to economic reasons and the limitations of implantation technology, the number of applications is still small. With the development of economy and the popularization of implantation technology, it is believed that more heart failure patients will benefit from cardiac resynchronization therapy and rebuild a better and happy life.