It is possible that staying up late can cause heart pain, but there are many causes of heart pain. If a teenager has heart pain after staying up late, it may be neuralgia, except that this neuralgia is manifested in the chest and can be mistaken for heart pain. If you are a middle-aged or elderly patient, especially if you have hypertension or diabetes, it is often easy to induce heart disease, and once you have heart pain, it is likely to be an angina attack. If the heart pain is severe and lasts for more than 20 minutes without relief, it may evolve into myocardial infarction, because staying up late is the most important cause of heart disease, hypertension disease and cerebrovascular disease.