After staying up late, consider whether there is coronary artery spasm, such as variant angina, arrhythmia, etc. If there is more serious precordial pain after staying up late, you should immediately consult a doctor at a hospital to improve relevant examinations such as electrocardiogram, cardiac ultrasound and, if necessary, coronary angiography to clarify the cause of pain and treat it in time. If the pain is denied by examination and is caused by cardiovascular factors, other diseases such as retrosternal burning pain caused by gastroesophageal reflux disease should be considered, and gastroscopy can be performed if necessary. In summary, staying up all night is very harmful to the body, when the body discomfort, should be timely in the hospital, improve the relevant examination and timely treatment, in addition to staying up all night is a bad way of life, as far as possible to avoid staying up all night.