Sciatic nerve pain is aggravated at night and alleviated during the day mainly due to neurological factors, postural factors, environmental factors and psychological factors. 1. Neurological factors: the sympathetic nerve is inhibited during sleep, the parasympathetic nerve is excited, and the adrenal glucocorticoid secretion level decreases, which can lead to a decrease in the human body’s tolerance to pain, thus leading to increased pain at night. 2. Positional factors: the human body at night when resting for a long time to maintain a position or because the mattress is too soft, the spine extra pressure triggered by sciatic nerve pain aggravation. 3. Environmental factors: the temperature difference between day and night is large, the temperature may drop at night, compared with the daytime temperature difference is large, the sciatic nerve is cold, stimulation triggered by pain aggravation. 4. Psychological factors: because of the night attention is more concentrated on the pain stimulus is more sensitive, psychological self-suggestion also exists. Sciatica is severe at night and decreases during the day. It is recommended that patients consult a doctor in time to find out the cause of their sciatica and follow the doctor’s instructions for standardized treatment.