A cough with yellow sputum should be registered with a respiratory medicine department. A cough with yellow sputum is one of the more common symptoms of the respiratory system. It can be seen in many diseases, such as acute bronchitis, chronic bronchitis, bronchiectasis, and lung abscess. It is recommended to improve the CT of the lungs and sputum culture, and further blood tests for inflammatory indicators such as routine blood tests, C-reactive protein, calcitoninogen, etc. If the CT indicates infectious lesions and the inflammatory indexes are significantly higher than normal, oral anti-inflammatory drugs such as penicillin or cephalosporins such as cefadroxil should be administered, and cough and sputum relief drugs should be administered along with anti-infective treatment.