Creatinine 118μmol/L and blood urea nitrogen 8.29mmol/L usually need to be treated according to their causes. If it is due to physiological reasons such as excessive protein intake that causes creatinine and urea nitrogen to rise, no treatment is needed at this time; if it is due to pathologic reasons such as glomerulonephritis and other diseases that cause creatinine and urea nitrogen to rise, oral medication and other treatments are needed. Creatinine is a toxin produced by muscle metabolism, while blood urea nitrogen is the end product of protein metabolism in the body, both are excreted from urine through glomerular filtration, which is affected by various factors, and may cause the elevation of creatinine and blood urea when eating too much protein food or abnormal kidney function. The normal value of blood creatinine is 53~106μmol/L for men and 44~97μmol/L for women, and the normal value of blood urea nitrogen is 3.2~7.0mmol/L. Therefore, creatinine 118μmol/L and blood urea nitrogen 8.29mmol/L indicate elevated creatinine and urea nitrogen. If it is caused by physiological reasons such as excessive protein intake, there is usually no need for treatment at this time; if it is due to pathologic reasons such as glomerulonephritis and other diseases, active treatment of the primary disease, lowering blood pressure, lowering urinary protein, and slowing down the progression of renal function may be required. Commonly used drugs include captopril, valsartan, etc. Even immunosuppressants such as prednisone and cyclophosphamide will be applied. All of the above medications should be used under doctor’s guidance, avoid self-medication. If the patient found that creatinine, urea nitrogen increased, it is recommended to go to the regular hospital in time, after clarifying the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.