Some congenital heart disease is caused by chromosomal problems, but not all. Congenital heart disease is a congenital malformation resulting from abnormal cardiovascular development during fetal life, which may be caused by genetic factors, environmental factors acting alone or as a result of a combination of factors. 1. Genetic factors: including chromosomal abnormalities, single gene or polygenic genetic defects and so on. Chromosomal abnormalities are mainly Down’s syndrome, Turner’s syndrome, and congenital heart disease caused by chromosomal abnormalities such as Cat’s Eye Syndrome and Cat’s Bark Syndrome. 2. Environmental factors: for example, the advanced age of pregnant women, colds and fever during pregnancy, medication during early pregnancy, diabetes in the mother during pregnancy and toxoplasmosis infection, etc., may lead to congenital heart disease in the fetus. Congenital heart disease is not always caused by chromosomal problems, there may be other reasons, patients with congenital heart disease should promptly go to the hospital cardiovascular and other related departments.