Data from epidemiologic surveys in recent years suggest that 2 out of every 3 outpatients are patients with a variety of pain conditions or symptoms. The rate of persistent pain in the elderly is higher than in the general population, with 78% of people aged 60-69 years and 64% of people aged 80-89 years having pain problems. Therefore, some experts believe that pain is the “5th most important vital sign of human beings” after respiration, pulse, body temperature and blood pressure. There is a popular saying: “Toothache is not a disease, but pain can kill you.” People always think that pain is just an external manifestation of disease, and as long as the disease is cured, the pain will disappear. But what if the disease causing the pain cannot be cured? Or if the disease is cured, but the pain remains? At this time, people often do not know what to do. Pain can be a symptom of an internal organ disease, such as acute abdomen, angina, etc. It can also be a symptom of nerve/vascular tissue damage. It can also be an irritation of the nervous/vascular tissue, such as migraine, trigeminal neuralgia, neck and shoulder pain, intercostal neuralgia, low back pain, cancer pain and post-herpetic pain. Due to trauma and surgery, infection and other causes of pain for acute pain, and chronic disease, degenerative diseases caused by pain is called chronic pain, such as cervical spondylosis, lumbar disc herniation diabetic neuralgia, cancer pain caused by intermittent, migratory pain, osteoarthritis caused by degenerative changes in bone joints, rheumatism, and so on. In short, the causes and pathogenesis of pain and pain disorders are intricate. The main points of pain management in the following aspects: 1, feel the pain, looking for pain relief treatment and determine its cause is equally important. 2, pain needs to be observed for its nature and location to facilitate judgment. 3, Anti-inflammatory painkillers should not be used routinely as they also have more pronounced side effects. 4, mild and moderate muscle and bone pain, can consider the use of acetaminophen. 5.Strong analgesics can be added for severe pain. 6.Neuropathic pain should be combined with the use of antiepileptic painkillers. 7.When the drugs can not stop the pain, can cooperate or joint use of non-pharmacological therapies such as surgical treatment. 8, when the pain persists, to seek medical help in the hospital. If you encounter a pain situation that is difficult to grasp, do not abuse painkillers, so as not to cover up the condition and delay the diagnosis, you should go to the hospital in time. For the analgesia of chronic pain, multidisciplinary integrated treatment is necessary. Neighboring disciplines in the treatment of “pain” not only cooperate with each other, but also have a clear distinction between the division of labor. For example, the Department of Anesthesiology to surgical pain relief and treatment of acute pain; orthopedics is mainly surgical treatment of bone injuries; neurology and oncology is mainly drug treatment of pain; rehabilitation and physiotherapy department is mainly physical methods of treatment. The treatment means of pain medicine has shifted from pure drug treatment to multidisciplinary comprehensive treatment with advanced medical technologies such as nerve block, radiofrequency thermo-coagulation, spinal cord electrical stimulation, etc. Chronic intractable pain is a disease in itself, and severe or prolonged pain will cause disorders in the function of various organs and systems of the human body. For a long time the understanding of pain and pain control measures are unsatisfactory, but also has made the patient due to the pain can not be controlled in time and relieve the suffering of pain, many people lose their labor force. Therefore, we should pay attention to the early diagnosis and treatment of pain diseases, mainly to strengthen the primary acute diseases of timely treatment to avoid delayed recurrence; but also for chronic diseases adhere to the long-term rational use of medication, to prevent the occurrence of complications, reduce the incidence of chronic pain. Pain episodes should seek specialized doctors for diagnosis and treatment of the correct use of analgesic measures to reduce misdiagnosis and misdiagnosis.