1, electrolyte disturbance and acid-base balance imbalance This is mainly caused by the loss of electrolytes during CRRT without timely replenishment or the use of sodium citrate as an anticoagulant. Electrolyte disorders can be avoided by replenishing electrolytes with dialysis fluid or replacement fluid. Recent studies have reported that electrolyte disturbances and acid-base imbalance during sodium citrate anticoagulation are uncommon, and when they do occur, they are transient. Complications of metabolic disorders occurring during sodium citrate anticoagulation can be regulated in time. Bleeding is one of the common complications of CRRT, including bleeding associated with indwelling intravenous catheters and bleeding due to anticoagulation. bleeding is a major complication in CRRT with heparin anticoagulation. the Tolwani study found that the risk of bleeding was lower with local anticoagulation with citrate than with systemic anticoagulation with heparin. another study found that the incidence of bleeding in humans with sodium citrate anticoagulation was 5.7%, which was significantly lower than the incidence of bleeding with heparin anticoagulation. Another study found that the incidence of bleeding in humans with sodium citrate anticoagulation was 5.7%, which was significantly lower than that with heparin anticoagulation (approximately 14.5%). Because of the prolonged filter life, controlled electrolyte disturbance and lower risk of bleeding with sodium citrate anticoagulation, the latest domestic and international guidelines recommend the use of sodium citrate anticoagulation in patients requiring CRRT where citrate is not contraindicated, especially for patients at high risk of bleeding. 3. Cardiovascular complications Excessive ultrafiltration speed, fluid imbalance, too low target dry weight setting, too low sodium level of dialysate or replacement fluid, and factors of the heart itself can lead to the occurrence of hypotension. During treatment, patients should be closely monitored for blood pressure, heart rate, hemodynamics and other indices to enhance volume management, adjust ultrafiltration speed and improve cardiac function to reduce the occurrence of hypotension. 4.Other CRRT patients often have chills or shivering due to the input of large amount of replacement fluid or dialysis fluid and the low temperature caused by the loss of heat from extracorporeal circulation. It is recommended to keep the room temperature at 18-28℃, humidity at 50-70%, closely monitor the change of patient’s body temperature and the magnitude of body temperature drop, observe the temperature of peripheral circulation, whether the patient has chills or shivering, and pay attention to keeping the patient warm.