Nodular itchy rash belongs to the chronic disease, may not be able to achieve a radical cure, but can be through the general treatment, physical therapy, medication and other ways to improve the symptoms. 1. General treatment: pay attention to personal hygiene, avoid scratching the lesions with hands, patients can try to cut the nails short, and apply local moisturizing cream after bathing to help the disease recover. 2. Physical therapy: if the nodular itchy rash is more stubborn, you can choose the way of liquid nitrogen freezing treatment to improve the symptoms. 3. Medication: Patients can follow the doctor’s instructions to use corticosteroids, such as Trimethoprim Econazole Cream, Denuded Cream to relieve itching. If local medication fails to provide relief, systemic medication can be used, such as oral isotretinoin and prednisone. Nodular itchy rash should be taken under the guidance of a doctor to take treatment means, so it is recommended that the patient timely consultation, follow the doctor’s instructions to take standardized treatment, do not private treatment, so as not to lead to adverse consequences.