With the development of medicine, pancreaticoduodenectomy has become a routine operation. Most hospitals of different levels can carry out, but safety is still an issue, I summarize the following points of experience: (for the safety of surgery, especially pancreatic leakage) 1, the use of roux-y way or broun anastomosis can make the jejunal bridge collaterals where the pancreatic-biliary anastomosis is located empty smoothly, providing favorable conditions for the healing of the two anastomoses. Experienced surgeons know that the emptying of the stomach cannot be compared with that of the small intestine. Therein lies the reason for the high rate of postoperative complications with the traditional CHILD approach. This is the first important point for safety improvement. Gao Shunliang, Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Zhejiang University School of Medicine, Zhejiang, China 2. Pancreatic duct-to-jejunum mucosal anastomosis is used. About this point, probably need not say more, today’s Japanese and American teaching hospitals are using this approach. The principle is even simpler and clearer. Personally, after adopting the above two methods, the safety of pancreaticoduodenectomy is not much different from that of major gastrectomy.