The surgical treatment of pancreatic diseases is a difficult problem in abdominal surgery, and the anatomical site of the pancreas determines the complexity of pancreatic surgery, which requires high surgical skills and rich clinical experience. Although the mortality rate of pancreaticoduodenectomy has been reduced to less than 2% in recent years due to the improvement of pancreatic surgery techniques, the complication rate is as high as about 47%. Such a high complication rate makes pancreatic surgery a forbidden area in the field of general surgery. And laparoscopic pancreatic surgery has become a peak that no one has climbed. In recent years, with the invention of laparoscopic hemostatic instruments, difficult laparoscopic surgical procedures have become possible. For example, difficult pancreaticoduodenectomy, distal pancreatectomy and hepatectomy. In laparoscopic pancreatic surgery, the higher complication rate and the rate of intermediate open abdomen make it a controversial point because the advantages of laparoscopic pancreaticoduodenectomy are still far from being realized. In contrast, laparoscopic distal pancreatic resection is the most performed procedure with the highest number of cases, the most successful, and the one that best reflects the advantages of minimally invasive laparoscopic techniques. Compared with traditional open surgery, laparoscopic pancreatic surgery has the advantages of less trauma, faster recovery, lower complication rate, shorter hospital stay and aesthetics. Our data show that the postoperative complications of laparoscopic insulinoma resection are much lower than those of classical open surgery. Since 2002, laparoscopic insulinoma resection, laparoscopic distal pancreatic resection, pancreatic pseudocyst-jejunum Roux-en-Y anastomosis and palliative surgery for pancreatic cancer, such as: laparoscopic gastric-jejunal Roux-en-Y anastomosis, biliary-intestinal anastomosis and laparoscopic retroperitoneal plexus block, have been performed in the Department of General Surgery of Peking Union Medical College Hospital. Indications for laparoscopic distal pancreatectomy: benign and low-grade malignant tumors of the tail of the pancreas, including cystic tumors of the pancreas, endocrine tumors of the pancreas and lymphomas; chronic pancreatitis and pseudocysts of the tail of the pancreas. It is controversial whether pancreatic cancer is an indication for laparoscopic pancreatic surgery, but early stage or small tumor size of pancreatic cancer can be treated by laparoscopic radical distal pancreatic resection. Surgical indications for laparoscopic pancreatic mass removal: tumor tumors located at the upper and lower margins of the pancreas, the tail of the pancreatic body and the ventral side of the pancreatic head. Contraindications are tumors located on the passive side of the pancreatic head, with the hooks in close proximity to the portal vein or the main pancreatic duct. Indications for laparoscopic pancreatic pseudocyst-gastric anastomosis or cyst-jejunum Roux-en-Y anastomosis surgery: pancreatic pseudocysts formed after acute and chronic pancreatitis. Especially for huge pancreatic pseudocysts, cyst-jejunum Roux-en-Y anastomosis is effective. The biggest advantage is that there is no surgical incision in the abdomen, quick recovery and few complications. Laparoscopic palliative surgery for pancreatic cancer is indicated for patients with advanced pancreatic cancer with obstructive jaundice or gastrointestinal obstruction, etc. Laparoscopic biliary-enteric anastomosis and gastrointestinal anastomosis can relieve patients’ pain. Transcatheter laparoscopic abdominal plexus block is indicated for patients with advanced stage with pain, and is particularly suitable for patients for whom opioid analgesics are ineffective.