Pancreatic disease causative factors mainly include surgery and trauma, papillary and peripheral diseases, endocrine metabolic disorders, autoimmune diseases, drugs and other factors. 1. Surgery and trauma: usually ERCP examination, duodenal surgery distal gastrectomy, etc., may cause inflammatory lesions in the pancreas, thus causing abdominal pain, vomiting and other uncomfortable symptoms. 2. Diseases in and around the cleavage: usually due to sphincter of Oddi dysfunction, tumors in the jugular abdomen, diverticulum, duodenal obstruction, input collaterals syndrome and other diseases, thus causing inflammatory changes in the pancreas. 3. Endocrine metabolic disorders: common in hypercalcemia, hyperparathyroidism, diabetic coma and other diseases, because these diseases will have an impact on the function of the pancreas, leading to pancreatic inflammation. 4. Autoimmune diseases: such as systemic lupus erythematosus, rheumatoid arthritis, necrotizing vasculitis, IgG4-related diseases, etc., which will affect the immune function of the body and lead to pancreatic lesions. 5. Drugs: Common drugs include azathioprine, sulfonamides, thiazide diuretics, tetracycline, glucocorticoids and so on, which will affect the secretion of pancreas and lead to pancreatitis. In addition, biliary tract diseases such as bile duct stones and long-term heavy drinking and smoking are also common causes of pancreatic diseases. When inflammatory changes in the pancreas or other uncomfortable symptoms appear, it is recommended to consult a doctor in time for treatment.