Thinness in diabetic patients may be related to poor glycemic control, where a large amount of sugar is excreted through the urine and cannot be effectively utilized, resulting in the depletion of body fat and the appearance of thinness. Patients may be given oral insulinotropic agents or treated with insulin. Insulin stimulants can increase the amount of insulin secretion, insulin can increase body weight while lowering blood glucose, preventing the patient from further wasting, or exogenous insulin can be given for treatment, which can play a role in lowering glucose and increasing body weight appropriately at the same time. Commonly used insulin agonists glimepiride, gliquidone, etc. There are several types of insulin, and it is important to choose a suitable glucose-lowering program under the guidance of a professional physician. In the process of using insulinotropic agents and insulin to lower blood glucose, it is necessary to strengthen the monitoring of blood glucose to avoid hypoglycemia. In addition, diabetic patients with emaciation need to pay attention to whether they eat too little, exercise too much, and need to rule out the occurrence of other diseases that lead to weight loss, such as hyperthyroidism, tumors and so on. It is recommended that patients go to a specialized hospital for treatment.