Many patients in advanced stages of tumor often give up treatment, and as a result, the quality of survival is compromised. Generally speaking, tumor is divided into 4 stages, namely stage I, II, III and IV. Tumors that have developed to stage III-IV are called advanced tumors. Clinically, metastatic cancer with unknown primary foci and malignant tumors that recur and metastasize after radical surgery or radiotherapy are also called advanced stage tumors. According to incomplete statistics, there are about 5 million patients with advanced tumors in China, accounting for almost half of the malignant tumors. With the development of medical science and technology, people have a new understanding of how to treat advanced tumors. Through multidisciplinary comprehensive treatment, including chemotherapy (chemotherapy), radiotherapy (radiotherapy), surgery, Chinese herbal medicine, biological response modifier therapy, endocrine therapy, interventional therapy, etc., we can effectively control the deterioration of the disease by taking advantage of the strengths and weaknesses. Chemotherapy can be widely used in the treatment of many kinds of tumors. Targeted whole-county chemotherapy or local chemotherapy plays a major role in the effective treatment of advanced tumors. For example, advanced breast cancer, undifferentiated small cell lung cancer, malignant lymphoma, ovarian or testicular cancer (especially seminoma), Ewing sarcoma, choriocarcinoma, malignant staphyloma, nephroblastoma and some acute leukemia, even if the disease is advanced, as long as the application of chemotherapy is adhered to, it still has a certain degree of sensitivity. In addition, the treatment of advanced nasopharyngeal carcinoma and tongue cancer, such as superior vena cava compression syndrome and hypofractionated squamous carcinoma, is also sensitive. For patients with advanced gastrointestinal tumors, bladder cancer and some cancerous intracavitary effusion, local chemotherapy can play a role in reducing symptoms and stabilizing the disease, and then combined with systemic chemotherapy, the disease can achieve partial improvement. Radiation therapy is painless, and the treatment is carried out in stages, which is a light burden on the whole body and has a definite therapeutic effect. It is very important for advanced tumors that cannot be cured, such as some lung cancer, breast cancer and other gynecological tumors. Radiotherapy can also effectively shrink the tumor and quickly relieve the pain, suffocation, obstruction, bleeding and bad odor caused by tumor necrosis or compression, such as esophageal obstruction, tracheal tumor, cervical cancer and some unresectable skin cancer (or visible cancer). In case of bone metastasis or bone invasion, radiotherapy is the best way to relieve the patient’s pain if it is a local metastasis. In addition, radiotherapy is the best treatment for brain metastasis. The lesion of advanced tumor is no longer limited to a certain organ or a certain part of the tissue, so surgical resection cannot play a radical role, but it does not mean that surgical treatment is useless for patients with advanced tumor. The right time and the right method for surgical treatment, such as tumor reduction for gynecological tumor, reconstruction of gastrointestinal tumor, urinary tract tumor and bile duct cancer, palliative resection for advanced breast cancer, etc., can remove some obstacles for the subsequent treatment of patients. Most advanced tumors can be treated with Chinese herbal medicine, such as mercury, arsenic, toxic plants and insects, but improper application can cause considerable side effects. Treatment with biological response modifiers can be used as an adjuvant treatment for advanced tumors, adjusting the state of imbalance to normal range to control the growth of tumors or even make them subside. In some malignant tumors, there are a certain number of hormone targets (receptors) in the cells. The mechanism of endocrine therapy is that drugs and hormones in the body compete with hormone receptors to curb or even stop tumor proliferation. It can be applied to breast cancer, thyroid cancer, prostate cancer, kidney cancer, gastrointestinal tract cancer, endometrial cancer, etc. in early and late stages. Interventional therapy is a discipline developed in China only in the 1980s. At present, it is more commonly used for liver cancer, lung cancer, metastatic lung cancer, advanced gastrointestinal tumors, gynecological tumors and so on. In addition, in recent years, multi-bullet, ultrasonic knife and X─knife have also played a more significant role in the treatment of advanced tumors. It can be seen that as long as scientific, reasonable and standardized treatments are applied, advanced tumor patients can achieve more satisfactory results, which is helpful to improve their survival quality.