Objective: To retrospectively analyze the effect of different post-nasal endoscopic management of some common benign lesions of the nasal cavity-sinus and their local medication methods on the treatment outcome. Methods: There were 236 patients with sinusitis, nasal polyps, deviated septum, fungal sinusitis, nasal hemangioma, involute papilloma, sinus cyst and hemorrhagic necrotizing intraperitoneum who underwent nasal endoscopic surgery in our department in the past 5 years and had complete data at a follow-up of more than 1 year, with a mean of 1.5 years after surgery. Routine management included nasal endoscopic clearance of surgical cavity secretions, surgical cavity vesicles and granulations. Corticosteroid nasal spray was administered twice daily for a total of 3 weeks. For those who were found to have nasal adhesions, scarred adhesions or narrowing of the maxillary sinus orifice, they were separated endoscopically, and part of the mucosa and its submucosal tissues at the original adhesion site were excised, and some patients were placed with infiltrated 5-fluorouracil (5-FU) expansion sponges for filling. 3 patients with involuted papilloma were treated with interferon a-2b (5miu/1ml) for local submucosal multipoint injection of the sinus orifice. Miniature maxillary sinus drainage stents were placed endoscopically in some patients with concurrent postoperative maxillary sinus orifice scar overgrowth. Results: 83.47% (197/236) were cured, 11.44% (27/236) were improved, and the overall effective rate was 94.92% (224/236). The results of the analysis of patients with no effect were: 3 patients with simple sinusitis, nasal polyps with sinusitis, patients with deviated nasal septum with sinusitis and nasal adhesions occurred after nasal hemangioma, respectively; 1 patient with simple sinusitis with diabetes mellitus had a recurrence of sinus inflammation after surgery. 2 patients with nasal polyps had a recurrence of polyps during follow-up. The rest of the patients were cured or clinically treated effectively. The analysis of the effect of different postoperative management methods showed that among the 195 patients treated conventionally, the main causes of ineffectiveness in 4 cases were recurrence of postoperative sinus inflammation in 1 patient with concomitant diabetes, recurrence of nasal polyps in 2 cases, and sinus stenosis and nasal adhesions in 1 case. After conventional treatment and simple adhesion separation of nasal adhesions, 7 out of 13 patients failed, all due to re-occurrence of adhesions. In one patient with a postoperative septal hematoma complicated by septal correction, routine postoperative management and hematoma removal were performed, and then nasal adhesions occurred. The rest of the patients (including 24 patients with concomitant nasal adhesions who had local infiltration of 5-FU expansion sponges or endoscopic placement of miniature maxillary sinus drainage stents, and 3 patients with involuted papilloma who had local submucosal basal interferon injections) did not experience any other complications during the follow-up period. Conclusion: Postoperative cavity management after nasal endoscopy will have a critical impact on the outcome. In patients with concomitant postoperative nasal adhesions, appropriate methods (including local placement of an infiltrated 5-fluorouracil (5-FU) expansion sponge or endoscopic placement of a miniature maxillary sinus drainage stent) should be selected for management after separation of the adherent tissue, which can effectively prevent the occurrence of re-adhesions. In patients with involuted papilloma, local injection of interferon can effectively prevent tumor recurrence and is a simple and effective treatment method.