In every clinic, hypertensive patients keep asking how to pay attention to the diet of hypertension, and some even bring newspapers or certain health products and ask me if they can eat them.
Here I give you a detailed reply: Huang Hui, Department of Cardiovascular Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University When treating hypertension, in the use of monoamine oxidase inhibitors, etc., patients should not eat foods high in casein during the medication, such as lentils, cured meat, cured fish, cheese, sour milk, bananas, raisins, beer and red wine. This is because tyrosine may cause a large release of norepinephrine, which is a sharp rise in blood pressure and hypertensive crisis. So what is a monoamine oxidase inhibitor? It mainly includes mainly certain hydrazine and non-hydrazine compounds which inhibit monoamine oxidase and exhibit antidepressant effects, they are phenylhydrazine, isocarboxyhydrazine, nilamides of hydrazine. The non-hydrazine class of anti-phenylcyclopropanolamine. This class of drugs produces antidepressant effects by inhibiting monoamine oxidase, reducing the metabolic inactivation of catecholamines, contributing to increased levels of catecholamines at synaptic sites, and having hypotensive effects. In addition to the inhibition of monoamine oxidase, these drugs also have an inhibitory effect on drug metabolizing enzymes in the liver. These drugs have more side effects and can produce central excitation. Induces psychotic episodes and has hepatotoxicity. In terms of antihypertensive drugs, it mainly refers to: Eugenol [Alias] Bargyline; Propargyl Methyl Benzylamine; Eugenol , Pargyline [Foreign Name] Pargyline [Indications] Clinically, it is mainly used for severe hypertension, especially in those who are not satisfied with the efficacy of other antihypertensive drugs, those who have more self-conscious symptoms, especially mental and emotional are poor and those who have more serious adverse reactions to blood pressure. This product is not recommended for mild hypertension, but can be used alone or in combination with oral diuretics for moderate hypertension. Dosage and Administration
Oral: Start with 10mg per dose, 1 to 2 times daily. After adaptation, it can be gradually increased to 30~40mg per day, divided into 1~2 doses. When the blood pressure drops too much, then reduce the dosage appropriately. Maintenance 20mg per day (10mg for a few patients), taken once a day. Precautions] 1. When the dosage is too large, it may cause postural hypotension, sometimes dry mouth, appetite discomfort, insomnia, dreaminess and other symptoms. 2, the antihypertensive effect appears slowly, the effect time is long, the patient response has a large body differences, so the dosage should be small at the beginning of treatment, and then gradually increase, and increase or decrease at any time to maintain the appropriate blood pressure level. 3, with hyperthyroidism, liver and kidney dysfunction and pheochromocytoma patients are contraindicated. 4. This product should not be used in combination with ephedrine, amphetamine, promethazine, ethanol, methyldopa, reserpine, antihypertensive agent, guanethidine, etc. 5.During the period of administration, avoid eating food containing high amount of tyramine, because the tyramine in food is destroyed by monoamine oxidase in liver and intestine under normal condition, but when this enzyme is inhibited by this product, tyramine will be stored in large amount in the body, which can cause hypertensive crisis and even death. It is not widely used at present. Therefore, if you are not taking the above mentioned drugs, you do not need to restrict the intake of a particular food in addition to low salt and low fat in your diet to avoid nutritional imbalance.