Purpura nephritis, a systemic small-vessel vasculitis mediated by immune complexes, purpura nephritis is also an immune complex nephritis, the pathogenesis of which is mainly through humoral immunity, but also involves cellular immunity, some cytokines and inflammatory mediators, and coagulation mechanisms are involved in the pathogenesis of the disease. There is a racial predisposition to the development of this disease, and some studies suggest a genetic relationship. The main clinical manifestations are skin purpura, hematuria and proteinuria, and there may be arthralgias, abdominal pain, and blood in the stool. The clinical presentation varies widely and can present as either simple microscopic hematuria or carnivorous hematuria, nephrotic syndrome with massive proteinuria and swelling, or acute renal failure. Its etiology is complex, and a variety of causes can lead to the development of the disease, either as a result of allergic reactions caused by bacterial, viral and parasitic infections, or as a result of allergies to certain drugs and foods, or as a result of plant pollen, insect bites, cold stimulation, etc. It is often associated with bacterial and viral infections, drugs, food such as fish, shrimp and crab, foreign bodies such as pollen, dust mites, mosquitoes, animal feathers, paint, etc., or vaccinations. This disease belongs to the category of “purple spots”, “epistaxis” and “blood in urine” in traditional Chinese medicine. The etiology of the disease is generally believed to be caused by heat in the blood and blood in the camp and forcing the blood to move delicately, or stasis in the blood and blocking the veins and channels, or yin deficiency and fire and damage to the blood and channels, or spleen and kidney deficiency and weakness in blood intake, and the treatment is based on clearing the camp and cooling the blood, activating the blood and removing stasis, nourishing the yin and clearing the fire, and tonifying the qi and regulating the blood. There are also doctors according to the different stages of the disease treatment, the early stage of the disease for the poisonous heat is embedded, forced blood delusion behavior key, manifested as the skin purpura, the poisonous heat of the evil invade the kidney through the meridian, damage to the veins and ligaments, urine blood, should be clearing heat and detoxification, cooling blood to stop bleeding as the treatment, should focus on clearing heat and detoxification; the middle of the disease to blood heat internal stasis as the main pathogenesis, at this time the poisonous evil gradually removed and blood heat fighting knot, purpura sometimes light and sometimes heavy, but urine blood continues, the treatment should be clearing heat and relieving dampness, blood stasis as the main pathogenesis. The treatment should be based on clearing heat and dampness, cooling blood and invigorating blood; in the late stage of the disease, the purpura is not healed for a long time or mismanaged, consuming qi and blood, damaging spleen and kidney, forming a deficient and real mixed evidence that heat evil is not removed and positive qi is injured, it is appropriate to use the method of strengthening spleen and kidney, replenishing qi and nourishing blood, or supporting positive and dispelling evil. The allergic purpura nephritis pathogenesis and symptoms are quite similar to the warm disease heat into the blood part of the evidence, both wind-heat poisonous evil from the external invasion of muscle couples, from the surface into the interior, deep camp blood, fumigation blood, and accumulated heat poison long ambush blood part of the internal and external combination of evil, heat poison gelation does not resolve, appear clinical symptoms. We have staged the treatment according to the different clinical characteristics of the patients, and divided it into the following three formulae: 1, Rhizoma Dihuang Tang formulae – allergic purpura nephritis general disease Pathogenesis: internal disturbance of the evil, heat in the blood, forcing the blood to move, and blood ligament damage Symptoms: no obvious cause directly appearing skin purpura Treatment: Clearing the blood, detoxifying and dispersing blood stasis, adding and subtracting Rhizoma Rhizoma Dihuang Tang: 60-90g of water hyacinth, 30 of raw earth, 15 of tannin, 30 of red peony, 15 of raw licorice, 30 of rhizome, 30 of white foxglove, 15 of northern sage, 15 of genkoshen, 15 of small thistle, 15-30 of formula: Heart is the master of blood, and also the master of gods. Heat disturbs the heart and the mind, causing agitation and fainting; forcing the blood to travel, blood does not follow the meridians and overflows out of the veins, resulting in bleeding from various parts such as vomiting, epistaxis, blood in stool, blood in urine, etc. The blood away from the meridians is all stasis, and the stasis is blocked in the body, resulting in hair spots; heat toxins in the blood deplete the fluid in the blood, resulting in purple-red and dry tongue. If the heat is not cleared, the blood will be restless, if the blood is not dispersed, the stasis will not go away, if the yin is not nourished, the fire will not be extinguished, as Ye Tianshi said, “the blood will be afraid of consuming the blood and moving it, it must cool the blood and disperse it.” Treatment should be to clear heat and detoxify, cool the blood and disperse blood stasis as the method. The formula uses bitter salty cold rhinoceros horn to cool the blood and clear the heart and detoxify the heat, sweet bitter cold raw earth, cool the blood and nourish the yin and produce fluid, with bitter slightly cold red peony and hard slightly cold danpi, clearing heat and cooling the blood, invigorating the blood to disperse stasis and dissolve spots, cooling the blood and invigorating the blood to disperse stasis and use, so that the heat clearing the blood and no blood consumption moving the blood, cooling the blood and stopping the bleeding without leaving stasis of the drawbacks. Radix Glycyrrhiza glabra, Radix Rehmanniae, Radix Bupleurum, Radix Salviae Miltiorrhizae, Radix Ginseng, and Radix Artichoke strengthen the effect of nourishing Yin and detoxifying toxins, diuretic and laxative to stop bleeding. The heat sign is obvious plus Gardenia jasminoides, Scutellaria baicalensis, Phyllanthus alba, Shuyangquan 15; with sore throat plus Yinhua, forsythia 15, cicada 6, shanduan 6; blood in the stool plus Shengdiyu 12, fried Puhuang 10, rhubarb charcoal 9, cypress charcoal, the rash is purple and dark, does not subside day after day piercing Shanjia 5g, change with the symptoms. 2.Zi’an formula – allergic purpura nephritis severe disease mechanism: wind, drug, food and heat toxins, internal disturbance of the pericardium Symptoms: restlessness, thirst, lip anxiety, abdominal pain, skin purpura, urine and stool closed, red and vivid tongue, yellow fur, pulse count, treatment: clear heat and detoxify, subdue spasm and extinguish wind, open the orifice and calm the panic Prescription: Angong Niuhuang Wan and Zixue Dan 60, Huang Lian 9, Andrographis paniculata 12, Yu Jin 12, Citrus aurantium 12, Bitter ginseng 15, Comfrey 15, Gardenia jasminoides 12, Scutellaria baicalensis 12, Sheng Ma 15-30, Xuan Shen 15 Explanation: This evidence is due to the development of the disease process, the heat evil is overwhelming, internal trapped in the pericardium, injury and fluids, and induce liver wind. So choose a large dose of bitter-cold drainage and detoxification drugs, sweet cold and bitter cold, because purpura nephritis does not have symptoms such as delirium, so remove the gold and stone heavy town products, as the so-called take its intention without its medicine. The fever is obvious plus: gypsum 30-60, cold water stone 15; spotted rash purple dark, day long does not subside penetrating the 5g, add or subtract with the symptoms. 3, Yin Qiao San formula evidence – external sensation and induced allergic purpura nephritis mild pathogenesis: wind-heat on the lung health symptoms: dry mouth and cough, sore throat, urine short red or bloody urine, may have fever and headache, purpura does not appear, red tongue, thin yellow coating, floating pulse. Treatment: Cool, bitter and sweet, remove wind and detoxify the toxin. Remedies: Forsythia 12, Yinhua 15, bitter mandarin 6, peppermint 12, bamboo leaf 12, raw licorice 15, thorny mustard 12, tempeh 6, burdock 15, rhizome 30, white foxglove 30, north sage 15, xuan shen 15, cyperus 15. It is in line with the pathogenic characteristics of “wind evil causes disease, easy to attack the Yang position, wind is light, good at moving several changes”, the sutra said: “the wind is lewd in the interior, the treatment is pungent and cool, accompanied by bitter and sweet; heat is lewd in the interior, the treatment is salty and cold, accompanied by sweet and bitter”; with silver flower, peppermint pungent and cool, heat dissipation and detoxification, bitter The herbs are used together to clear to remove the real effect. The two yangs rob each other, the poisonous heat rampages, consumes blood and moves blood, blood does not follow the meridian, the skin purple spots, vomiting blood, urine blood, blood in the stool, so the above three parties, often Yin Qiao San formula combined with Rhizoma Dihuang Tang formula, or Yin Qiao San formula combined with Zi An formula, in order to achieve the effect of internal elimination of evil, external dispel wind-heat poisonous evil, evil dispel positive security, and add or subtract with the symptoms of dispersing blood stasis, detoxification, laxative, nourishing Yin, hemostatic. The medicine should be added to enhance the therapeutic effect. At the same time, attention should be paid to protect the stomach qi to prevent the discomfort of subcardiac fullness, poor appetite and weakness after taking cold medicine for a long time.